4ee2

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{{STRUCTURE_4ee2| PDB=4ee2 | SCENE= }}
 
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===Crystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A Resolution===
 
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{{ABSTRACT_PUBMED_23100533}}
 
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==Function==
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==Crystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A Resolution==
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[[http://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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<StructureSection load='4ee2' size='340' side='right'caption='[[4ee2]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4ee2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EE2 FirstGlance]. <br>
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[[4ee2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EE2 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ee2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ee2 OCA], [https://pdbe.org/4ee2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ee2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ee2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ee2 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:023100533</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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__TOC__
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Kintzer, A F.]]
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[[Category: Large Structures]]
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[[Category: Krantz, B A.]]
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[[Category: Kintzer AF]]
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[[Category: Anthrax toxin]]
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[[Category: Krantz BA]]
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[[Category: Assembly]]
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[[Category: Cell-binding]]
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[[Category: Channel formation]]
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[[Category: Protein translocation]]
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[[Category: Toxin]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure of Anthrax Protective Antigen K446M Mutant to 1.91-A Resolution

PDB ID 4ee2

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