4ldm

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{{STRUCTURE_4ldm| PDB=4ldm | SCENE= }}
 
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===Crystal Structure of an RNA-free VP40 Octameric Ring===
 
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{{ABSTRACT_PUBMED_23953110}}
 
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==Function==
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==Crystal Structure of an RNA-free VP40 Octameric Ring==
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[[http://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM]] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
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<StructureSection load='4ldm' size='340' side='right'caption='[[4ldm]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4ldm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDM FirstGlance]. <br>
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[[4ldm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDM OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldm OCA], [https://pdbe.org/4ldm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldm RCSB], [https://www.ebi.ac.uk/pdbsum/4ldm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldm ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023953110</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Zaire ebolavirus]]
[[Category: Zaire ebolavirus]]
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[[Category: Ableson, D M.]]
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[[Category: Ableson DM]]
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[[Category: Bornholdt, Z A.]]
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[[Category: Bornholdt ZA]]
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[[Category: Saphire, E O.]]
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[[Category: Saphire EO]]
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[[Category: Ebolavirus matrix protein]]
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[[Category: Rna binding ring]]
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[[Category: Viral protein]]
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[[Category: Viral transcription regulation]]
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Current revision

Crystal Structure of an RNA-free VP40 Octameric Ring

PDB ID 4ldm

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