4ldb

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{{STRUCTURE_4ldb| PDB=4ldb | SCENE= }}
 
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===Crystal Structure of Ebola Virus VP40 Dimer===
 
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{{ABSTRACT_PUBMED_23953110}}
 
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==Function==
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==Crystal Structure of Ebola Virus VP40 Dimer==
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[[http://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM]] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
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<StructureSection load='4ldb' size='340' side='right'caption='[[4ldb]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4ldb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDB FirstGlance]. <br>
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[[4ldb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDB OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldb OCA], [https://pdbe.org/4ldb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldb RCSB], [https://www.ebi.ac.uk/pdbsum/4ldb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldb ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023953110</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Zaire ebolavirus]]
[[Category: Zaire ebolavirus]]
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[[Category: Ableson, D M.]]
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[[Category: Ableson DM]]
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[[Category: Bornholdt, Z A.]]
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[[Category: Bornholdt ZA]]
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[[Category: Saphire, E O.]]
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[[Category: Saphire EO]]
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[[Category: Assembly]]
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[[Category: Viral budding]]
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[[Category: Viral matrix protein]]
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[[Category: Viral protein]]
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[[Category: Viral transcription regulation]]
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Current revision

Crystal Structure of Ebola Virus VP40 Dimer

PDB ID 4ldb

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