4ewe

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{{STRUCTURE_4ewe| PDB=4ewe | SCENE= }}
 
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===Study on structure and function relationships in human Pirin with Manganese ion===
 
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{{ABSTRACT_PUBMED_23716661}}
 
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==Function==
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==Study on structure and function relationships in human Pirin with Manganese ion==
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[[http://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN]] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
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<StructureSection load='4ewe' size='340' side='right'caption='[[4ewe]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ewe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ewe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewe OCA], [https://pdbe.org/4ewe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ewe RCSB], [https://www.ebi.ac.uk/pdbsum/4ewe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
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==About this Structure==
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==See Also==
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[[4ewe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWE OCA].
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023716661</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Quercetin 2,3-dioxygenase]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Esaka, S.]]
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[[Category: Esaka S]]
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[[Category: Fu, R.]]
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[[Category: Fu R]]
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[[Category: Liu, A.]]
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[[Category: Liu A]]
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[[Category: Liu, F.]]
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[[Category: Liu F]]
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[[Category: Rehmani, I.]]
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[[Category: Rehmani I]]
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[[Category: Serrano, V.]]
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[[Category: Serrano V]]
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[[Category: Beta sandwich]]
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[[Category: Cupin]]
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[[Category: Metal binding protein]]
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[[Category: Nucleus]]
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[[Category: Protein binding]]
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[[Category: Signaling protein]]
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[[Category: Transcription cofactor activity]]
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Current revision

Study on structure and function relationships in human Pirin with Manganese ion

PDB ID 4ewe

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