4mgr

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'''Unreleased structure'''
 
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The entry 4mgr is ON HOLD
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==The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT==
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<StructureSection load='4mgr' size='340' side='right'caption='[[4mgr]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mgr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MGR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgr OCA], [https://pdbe.org/4mgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mgr RCSB], [https://www.ebi.ac.uk/pdbsum/4mgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref>
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Authors: Rui Wu, Raji Edayathumangalam, Roman Garcia, Yuguang Wang, Wei Wang, Cheryl A. Kreinbring, Alicia Bach, Jingling Liao, Todd Stone, Tom Terwilliger, Quyen Q. Hoang, Boris R. Belitsky, Gregory A. Petsko, Dagmar Ringe, Dali Liu
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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Description: The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP-and GABA-dependent transcriptional activator of gabT
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus subtilis]]
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[[Category: Large Structures]]
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[[Category: Bach A]]
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[[Category: Belitsky BR]]
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[[Category: Edayathumangalam R]]
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[[Category: Garcia R]]
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[[Category: Hoang QQ]]
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[[Category: Kreinbring CA]]
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[[Category: Liao J]]
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[[Category: Liu D]]
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[[Category: Petsko GA]]
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[[Category: Ringe D]]
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[[Category: Stone T]]
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[[Category: Terwilliger T]]
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[[Category: Wang W]]
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[[Category: Wang Y]]
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[[Category: Wu R]]

Current revision

The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT

PDB ID 4mgr

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