2nx8
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| - | [[Image:2nx8.jpg|left|200px]]<br /><applet load="2nx8" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2nx8, resolution 2.00Å" /> | ||
| - | '''The crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes'''<br /> | ||
| - | == | + | ==The crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes== |
| - | + | <StructureSection load='2nx8' size='340' side='right'caption='[[2nx8]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2nx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M6 Streptococcus pyogenes serotype M6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx8 OCA], [https://pdbe.org/2nx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx8 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TADA_STRP6 TADA_STRP6] Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).[HAMAP-Rule:MF_00972]<ref>PMID:17554781</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/2nx8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nx8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Streptococcus pyogenes | + | <references/> |
| - | [[Category: Hwang | + | __TOC__ |
| - | [[Category: Kim | + | </StructureSection> |
| - | [[Category: Lee | + | [[Category: Large Structures]] |
| - | + | [[Category: Streptococcus pyogenes serotype M6]] | |
| - | + | [[Category: Hwang KY]] | |
| - | + | [[Category: Kim YK]] | |
| - | + | [[Category: Lee W-H]] | |
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Current revision
The crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes
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