4fwh
From Proteopedia
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| - | {{STRUCTURE_4fwh| PDB=4fwh | SCENE= }} | ||
| - | ===Crystal structure of the Lon-like protease MtaLonC in complex with MG262=== | ||
| - | {{ABSTRACT_PUBMED_23897463}} | ||
| - | == | + | ==Crystal structure of the Lon-like protease MtaLonC in complex with MG262== |
| - | [[4fwh]] is a 1 chain structure with sequence from [ | + | <StructureSection load='4fwh' size='340' side='right'caption='[[4fwh]], [[Resolution|resolution]] 2.19Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meiothermus_taiwanensis Meiothermus taiwanensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FWH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIX:N-[(BENZYLOXY)CARBONYL]-L-LEUCYL-N-[(1R)-1-(DIHYDROXYBORANYL)-3-METHYLBUTYL]-L-LEUCINAMIDE'>CIX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwh OCA], [https://pdbe.org/4fwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fwh RCSB], [https://www.ebi.ac.uk/pdbsum/4fwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fwh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C9DRU9_9DEIN C9DRU9_9DEIN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Lon proteases are a unique family of chambered proteases with a built-in AAA+ (ATPases associated with diverse cellular activities) module. Here, crystal structures of a unique member of the Lon family with no intrinsic ATPase activity in the proteolytically active form are reported both alone and in complexes with three covalent inhibitors: two peptidomimetics and one derived from a natural product. This work reveals the unique architectural features of an ATP-independent Lon that selectively degrades unfolded protein substrates. Importantly, these results provide mechanistic insights into the recognition of inhibitors and polypeptide substrates within the conserved proteolytic chamber, which may aid the development of specific Lon-protease inhibitors. | ||
| - | + | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors.,Liao JH, Ihara K, Kuo CI, Huang KF, Wakatsuki S, Wu SH, Chang CI Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1395-402. doi:, 10.1107/S0907444913008214. Epub 2013 Jul 13. PMID:23897463<ref>PMID:23897463</ref> | |
| - | <ref | + | |
| - | [[Category: | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| + | </div> | ||
| + | <div class="pdbe-citations 4fwh" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Meiothermus taiwanensis]] | [[Category: Meiothermus taiwanensis]] | ||
| - | [[Category: Chang | + | [[Category: Chang CI]] |
| - | [[Category: Huang | + | [[Category: Huang KF]] |
| - | [[Category: Kuo | + | [[Category: Kuo CI]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the Lon-like protease MtaLonC in complex with MG262
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