2fc3

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{{STRUCTURE_2fc3| PDB=2fc3 | SCENE= }}
 
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===Crystal structure of the extremely thermostable Aeropyrum pernix L7Ae multifunctional protein===
 
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{{ABSTRACT_PUBMED_23989144}}
 
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==Function==
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==Crystal structure of the extremely thermostable Aeropyrum pernix L7Ae multifunctional protein==
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[[http://www.uniprot.org/uniprot/RL7A_AERPE RL7A_AERPE]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).
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<StructureSection load='2fc3' size='340' side='right'caption='[[2fc3]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc3 OCA], [https://pdbe.org/2fc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL7A_AERPE RL7A_AERPE] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fc3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fc3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Archaeal ribosomal protein L7Ae is a multifunctional RNA-binding protein that directs post-transcriptional modification of archaeal RNAs. The L7Ae protein from Aeropyrum pernix (Ap L7Ae), a member of the Crenarchaea, was found to have an extremely high melting temperature (&gt;383 K). The crystal structure of Ap L7Ae has been determined to a resolution of 1.56 A. The structure of Ap L7Ae was compared with the structures of two homologs: hyperthermophilic Methanocaldococcus jannaschii L7Ae and the mesophilic counterpart mammalian 15.5 kD protein. The primary stabilizing feature in the Ap L7Ae protein appears to be the large number of ion pairs and extensive ion-pair network that connects secondary-structural elements. To our knowledge, Ap L7Ae is among the most thermostable single-domain monomeric proteins presently observed.
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==About this Structure==
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Structure of the Aeropyrum pernix L7Ae multifunctional protein and insight into its extreme thermostability.,Bhuiya MW, Suryadi J, Zhou Z, Brown BA 2nd Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):979-88. doi: , 10.1107/S1744309113021799. Epub 2013 Aug 19. PMID:23989144<ref>PMID:23989144</ref>
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[[2fc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC3 OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[Ribosomal protein L7|Ribosomal protein L7]]
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</div>
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<div class="pdbe-citations 2fc3" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:023989144</ref><references group="xtra"/><references/>
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*[[Ribosomal protein L7/L12|Ribosomal protein L7/L12]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Aeropyrum pernix]]
[[Category: Aeropyrum pernix]]
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[[Category: Flowers, S L.]]
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[[Category: Large Structures]]
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[[Category: Gupton, T B.]]
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[[Category: Brown II BA]]
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[[Category: II, B A.Brown.]]
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[[Category: Flowers SL]]
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[[Category: Suryadi, J.]]
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[[Category: Gupton Jr TB]]
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[[Category: Zhou, Z.]]
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[[Category: Suryadi J]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: Zhou Z]]
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[[Category: Ribosome]]
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[[Category: Rna binding protein]]
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Current revision

Crystal structure of the extremely thermostable Aeropyrum pernix L7Ae multifunctional protein

PDB ID 2fc3

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