4b4d
From Proteopedia
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| - | {{STRUCTURE_4b4d| PDB=4b4d | SCENE= }} | ||
| - | ===Crystal structure of FAD-containing ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri=== | ||
| - | {{ABSTRACT_PUBMED_23984418}} | ||
| - | == | + | ==Crystal structure of FAD-containing ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri== |
| - | [[4b4d]] is a 1 chain structure with sequence from [ | + | <StructureSection load='4b4d' size='340' side='right'caption='[[4b4d]], [[Resolution|resolution]] 1.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4b4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_citri_pv._citri_str._306 Xanthomonas citri pv. citri str. 306]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4D FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4d OCA], [https://pdbe.org/4b4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4d RCSB], [https://www.ebi.ac.uk/pdbsum/4b4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8PMH0_XANAC Q8PMH0_XANAC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have solved the structure of ferredoxin-NADP(H) reductase, FPR, from the plant pathogen Xanthomonas axonopodis pv. citri, responsible for citrus canker, at a resolution of 1.5 A. This structure reveals differences in the mobility of specific loops when compared to other FPRs, probably unrelated to the hydride transfer process, which contributes to explaining the structural and functional divergence between the subclass I FPRs. Interactions of the C-terminus of the enzyme with the phosphoadenosine of the cofactor FAD limit its mobility, thus affecting the entrance of nicotinamide into the active site. This structure opens the possibility of rationally designing drugs against the X. axonopodis pv. citri phytopathogen. | ||
| - | + | Crystal Structure of the FAD-Containing Ferredoxin-NADP (+) Reductase from the Plant Pathogen Xanthomonas axonopodis pv. citri.,Tondo ML, Hurtado-Guerrero R, Ceccarelli EA, Medina M, Orellano EG, Martinez-Julvez M Biomed Res Int. 2013;2013:906572. doi: 10.1155/2013/906572. Epub 2013 Aug 1. PMID:23984418<ref>PMID:23984418</ref> | |
| - | <ref | + | |
| - | [[Category: Xanthomonas | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | [[Category: Ceccarelli | + | </div> |
| - | [[Category: Hurtado-Guerrero | + | <div class="pdbe-citations 4b4d" style="background-color:#fffaf0;"></div> |
| - | [[Category: Martinez-Julvez | + | == References == |
| - | [[Category: Medina | + | <references/> |
| - | [[Category: Orellano | + | __TOC__ |
| - | [[Category: Sanchez-Azqueta | + | </StructureSection> |
| - | [[Category: Tondo | + | [[Category: Large Structures]] |
| - | + | [[Category: Xanthomonas citri pv. citri str. 306]] | |
| + | [[Category: Ceccarelli EA]] | ||
| + | [[Category: Hurtado-Guerrero R]] | ||
| + | [[Category: Martinez-Julvez M]] | ||
| + | [[Category: Medina M]] | ||
| + | [[Category: Orellano EG]] | ||
| + | [[Category: Sanchez-Azqueta A]] | ||
| + | [[Category: Tondo ML]] | ||
Current revision
Crystal structure of FAD-containing ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri
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