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4mgr

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'''Unreleased structure'''
 
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The entry 4mgr is ON HOLD
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==The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT==
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<StructureSection load='4mgr' size='340' side='right'caption='[[4mgr]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mgr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MGR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgr OCA], [https://pdbe.org/4mgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mgr RCSB], [https://www.ebi.ac.uk/pdbsum/4mgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref>
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Authors: Wu, R., Edayathumangalam, R., Garcia, R., Wang, Y., Wang, W., Kreinbring, C.A., Bach, A., Liao, J., Stone, T., Terwilliger, T., Hoang, Q.Q., Belitsky, B.R., Petsko, G.A., Ringe, D., Liu, D.
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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Description: The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP-and GABA-dependent transcriptional activator of gabT
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus subtilis]]
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[[Category: Large Structures]]
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[[Category: Bach A]]
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[[Category: Belitsky BR]]
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[[Category: Edayathumangalam R]]
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[[Category: Garcia R]]
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[[Category: Hoang QQ]]
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[[Category: Kreinbring CA]]
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[[Category: Liao J]]
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[[Category: Liu D]]
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[[Category: Petsko GA]]
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[[Category: Ringe D]]
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[[Category: Stone T]]
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[[Category: Terwilliger T]]
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[[Category: Wang W]]
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[[Category: Wang Y]]
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[[Category: Wu R]]

Current revision

The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT

PDB ID 4mgr

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