2o18

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[[Image:2o18.gif|left|200px]]<br /><applet load="2o18" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2o18, resolution 2.20&Aring;" />
 
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'''Crystal structure of a Thiamine biosynthesis lipoprotein apbE, NorthEast Strcutural Genomics target ER559'''<br />
 
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==About this Structure==
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==Crystal structure of a Thiamine biosynthesis lipoprotein apbE, NorthEast Strcutural Genomics target ER559==
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2O18 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O18 OCA].
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<StructureSection load='2o18' size='340' side='right'caption='[[2o18]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2o18]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O18 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o18 OCA], [https://pdbe.org/2o18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o18 RCSB], [https://www.ebi.ac.uk/pdbsum/2o18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o18 ProSAT], [https://www.topsan.org/Proteins/NESGC/2o18 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APBE_ECOLI APBE_ECOLI] Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o18_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o18 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Acton, T B.]]
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[[Category: Acton TB]]
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[[Category: Baran, M C.]]
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[[Category: Baran MC]]
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[[Category: Cunningham, K.]]
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[[Category: Cunningham K]]
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[[Category: Fang, Y.]]
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[[Category: Fang Y]]
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[[Category: Hunt, J F.]]
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[[Category: Hunt JF]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Ma, L.]]
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[[Category: Ma L]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione GT]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Rost B]]
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[[Category: Rost, B.]]
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[[Category: Seetharaman J]]
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[[Category: Seetharaman, J.]]
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[[Category: Su M]]
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[[Category: Su, M.]]
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[[Category: Tong L]]
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[[Category: Tong, L.]]
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[[Category: Wang D]]
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[[Category: Wang, D.]]
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[[Category: Xiao R]]
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[[Category: Xiao, R.]]
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[[Category: CA]]
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[[Category: apbe]]
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[[Category: lipoprotein]]
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[[Category: nesg]]
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[[Category: northeast structural genomics consortium]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:13:23 2008''
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Current revision

Crystal structure of a Thiamine biosynthesis lipoprotein apbE, NorthEast Strcutural Genomics target ER559

PDB ID 2o18

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