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4b7w

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{{STRUCTURE_4b7w| PDB=4b7w | SCENE= }}
 
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===Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form===
 
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==Disease==
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==Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form==
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[[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[http://omim.org/entry/125850 125850]]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref> <ref>PMID:9243109</ref> <ref>PMID:9449683</ref>
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<StructureSection load='4b7w' size='340' side='right'caption='[[4b7w]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4b7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7W FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7w OCA], [https://pdbe.org/4b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7w RCSB], [https://www.ebi.ac.uk/pdbsum/4b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7w ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[4b7w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7W OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[https://omim.org/entry/125850 125850]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref> <ref>PMID:9243109</ref> <ref>PMID:9449683</ref>
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==Reference==
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== Function ==
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<references group="xtra"/><references/>
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[https://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barath, P.]]
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[[Category: Large Structures]]
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[[Category: Dudasova, Z.]]
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[[Category: Barath P]]
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[[Category: Kretova, M.]]
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[[Category: Dudasova Z]]
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[[Category: LeGuevel, R.]]
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[[Category: Kretova M]]
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[[Category: Leonard, G.]]
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[[Category: LeGuevel R]]
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[[Category: McSweeney, S.]]
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[[Category: Leonard G]]
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[[Category: Okvist, M.]]
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[[Category: McSweeney S]]
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[[Category: Ondrovicova, G.]]
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[[Category: Okvist M]]
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[[Category: Salbert, G.]]
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[[Category: Ondrovicova G]]
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[[Category: Skrabana, R.]]
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[[Category: Salbert G]]
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[[Category: Nuclear receptor]]
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[[Category: Skrabana R]]
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[[Category: Receptor]]
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Current revision

Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form

PDB ID 4b7w

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