4c45

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4c45" [edit=sysop:move=sysop])
Current revision (12:03, 20 December 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4c45| PDB=4c45 | SCENE= }}
 
-
===Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)===
 
-
==Function==
+
==Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)==
-
[[http://www.uniprot.org/uniprot/PHS2_HUMAN PHS2_HUMAN]] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
+
<StructureSection load='4c45' size='340' side='right'caption='[[4c45]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C45 FirstGlance]. <br>
-
[[4c45]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-
[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [https://pdbe.org/4c45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [https://www.ebi.ac.uk/pdbsum/4c45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c45 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PHS2_HUMAN PHS2_HUMAN] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Burgess-Brown, N.]]
+
[[Category: Bountra C]]
-
[[Category: Canning, P.]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Delft, F von.]]
+
[[Category: Canning P]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Kiyani, W.]]
+
[[Category: Kiyani W]]
-
[[Category: Kopec, J.]]
+
[[Category: Kopec J]]
-
[[Category: Shrestha, L.]]
+
[[Category: Shrestha L]]
-
[[Category: Vollmar, M.]]
+
[[Category: Vollmar M]]
-
[[Category: Yue, W W.]]
+
[[Category: Yue WW]]
-
[[Category: Lyase]]
+
[[Category: Von Delft F]]

Current revision

Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)

PDB ID 4c45

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c45"
Personal tools