2o3k
From Proteopedia
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| - | [[Image:2o3k.gif|left|200px]]<br /><applet load="2o3k" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2o3k, resolution 2.300Å" /> | ||
| - | '''Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY'''<br /> | ||
| - | == | + | ==Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY== |
| - | + | <StructureSection load='2o3k' size='340' side='right'caption='[[2o3k]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2o3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3k OCA], [https://pdbe.org/2o3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3k RCSB], [https://www.ebi.ac.uk/pdbsum/2o3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3k ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/FCY1_YEAST FCY1_YEAST] Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4. |
| - | [[ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/2o3k_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o3k ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Deaminase 3D structures|Deaminase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Korkegian AM]] | ||
| + | [[Category: Stoddard BL]] | ||
Current revision
Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
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