3rzc

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{{STRUCTURE_3rzc| PDB=3rzc | SCENE= }}
 
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===Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR===
 
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{{ABSTRACT_PUBMED_21810611}}
 
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==Function==
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==Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR==
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[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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<StructureSection load='3rzc' size='340' side='right'caption='[[3rzc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rzc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=LGN:N-[(2S,3R,4E)-1-{[ALPHA-D-GALACTOPYRANOSYL-(1- 3)-BETA-D-GALACTOPYRANOSYL-(1- 4)-BETA-D-GLUCOPYRANOSYL]OXY}-3-HYDROXYOCTADEC-4-EN-2-YL]HEXACOSANAMIDE'>LGN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzc OCA], [https://pdbe.org/3rzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzc RCSB], [https://www.ebi.ac.uk/pdbsum/3rzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Invariant NKT (iNKT) cells expressing a semi-invariant Valpha14 TCR recognize self and foreign lipid Ags when presented by the nonclassical MHCI homolog CD1d. Whereas the majority of known iNKT cell Ags are characterized by the presence of a single alpha-linked sugar, mammalian self Ags are beta-linked glycosphingolipids, posing the interesting question of how the semi-invariant TCR can bind to such structurally distinct ligands. In this study, we show that the mouse iNKT TCR recognizes the complex beta-linked Ag isoglobotrihexosylceramide (iGb3; Galalpha1-3-Galbeta1-4-Glcbeta1-1Cer) by forcing the proximal beta-linked sugar of the trisaccharide head group to adopt the typical binding orientation of alpha-linked glycolipids. The squashed iGb3 orientation is stabilized by several interactions between the trisaccharide and CD1d residues. Finally, the formation of novel contacts between the proximal and second sugar of iGb3 and CDR2alpha residues of the TCR suggests an expanded recognition logic that can possibly distinguish foreign Ags from self Ags.
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==About this Structure==
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Cutting Edge: Structural Basis for the Recognition of {beta}-Linked Glycolipid Antigens by Invariant NKT Cells.,Yu ED, Girardi E, Wang J, Zajonc DM J Immunol. 2011 Sep 1;187(5):2079-83. Epub 2011 Aug 1. PMID:21810611<ref>PMID:21810611</ref>
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[[3rzc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZC OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rzc" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[CD1|CD1]]
*[[CD1|CD1]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021810611</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Girardi, E.]]
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[[Category: Girardi E]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Yu, E D.]]
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[[Category: Yu ED]]
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[[Category: Zajonc, D M.]]
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[[Category: Zajonc DM]]
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[[Category: Antigen presentation]]
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[[Category: Glycolipid]]
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[[Category: Immune system]]
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[[Category: Nkt cell]]
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Current revision

Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR

PDB ID 3rzc

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