2ypn

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{{STRUCTURE_2ypn| PDB=2ypn | SCENE= }}
 
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===Hydroxymethylbilane synthase===
 
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==Function==
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==Hydroxymethylbilane synthase==
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[[http://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI]] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260]
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<StructureSection load='2ypn' size='340' side='right'caption='[[2ypn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2ypn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPN FirstGlance]. <br>
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[[2ypn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPN OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPM:3-[5-{[3-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)-5-METHYL-1H-PYRROL-2-YL]METHYL}-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>DPM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypn OCA], [https://pdbe.org/2ypn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypn RCSB], [https://www.ebi.ac.uk/pdbsum/2ypn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/2ypn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ypn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Porphobilinogen Deaminase|Porphobilinogen Deaminase]]
*[[Porphobilinogen Deaminase|Porphobilinogen Deaminase]]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hydroxymethylbilane synthase]]
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[[Category: Large Structures]]
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[[Category: Campbell, J W.]]
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[[Category: Campbell JW]]
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[[Category: Habash, J.]]
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[[Category: Habash J]]
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[[Category: Haedener, A.]]
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[[Category: Haedener A]]
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[[Category: Hao, Q.]]
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[[Category: Hao Q]]
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[[Category: Helliwell, J R.]]
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[[Category: Helliwell JR]]
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[[Category: Nieh, Y P.]]
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[[Category: Nieh YP]]
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[[Category: Raftery, J.]]
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[[Category: Raftery J]]
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[[Category: Schotte, F.]]
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[[Category: Schotte F]]
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[[Category: Ursby, T.]]
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[[Category: Ursby T]]
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[[Category: Weisgerber, S.]]
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[[Category: Weisgerber S]]
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[[Category: Wulff, M.]]
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[[Category: Wulff M]]
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[[Category: All alpha/beta]]
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[[Category: Biosynthesis of linear tetrapyrrole]]
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[[Category: Transferase]]
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Current revision

Hydroxymethylbilane synthase

PDB ID 2ypn

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