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4ifc

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{{STRUCTURE_4ifc| PDB=4ifc | SCENE= }}
 
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===Crystal Structure of ADP-bound Human PRPF4B kinase domain===
 
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{{ABSTRACT_PUBMED_24003220}}
 
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==Function==
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==Crystal Structure of ADP-bound Human PRPF4B kinase domain==
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[[http://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN]] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
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<StructureSection load='4ifc' size='340' side='right'caption='[[4ifc]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ifc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IFC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ifc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifc OCA], [https://pdbe.org/4ifc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ifc RCSB], [https://www.ebi.ac.uk/pdbsum/4ifc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ifc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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PRP4 kinase is known for its roles in regulating pre-mRNA splicing and beyond. Therefore, a wider spectrum of PRP4 kinase substrates could be expected. The role of PRP4 kinase in cancer is also yet to be fully elucidated. Attaining specific and potent PRP4 inhibitors would greatly facilitate the study of PRP4 biological function and its validation as a credible cancer target. In this report, we verified the requirement of enzymatic activity of PRP4 in regulating cancer cell growth and identified an array of potential novel substrates through orthogonal proteomics approaches. The ensuing effort in structural biology unveiled for the first time unique features of PRP4 kinase domain and its potential mode of interaction with a low molecular weight inhibitor. These results provide new and important information for further exploration of PRP4 kinase function in cancer.
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==About this Structure==
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Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.,Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, McManus J, Hoffmann D, Wang A, Wiederschain D, Rocnik J, Czechtizky W, Chen X, McLean L, Arlt H, Harper D, Liu F, Majid T, Patel V, Lengauer C, Garcia-Echeverria C, Zhang B, Cheng H, Dorsch M, Huang SM J Biol Chem. 2013 Sep 3. PMID:24003220<ref>PMID:24003220</ref>
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[[4ifc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024003220</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4ifc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Chen, X.]]
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[[Category: Chen X]]
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[[Category: Haas, K.]]
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[[Category: Haas K]]
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[[Category: McLean, L.]]
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[[Category: McLean L]]
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[[Category: Mechin, I.]]
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[[Category: Mechin I]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Kinase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of ADP-bound Human PRPF4B kinase domain

PDB ID 4ifc

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