2lww

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{{STRUCTURE_2lww| PDB=2lww | SCENE= }}
 
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===NMR structure of RelA-TAD/CBP-TAZ1 complex===
 
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{{ABSTRACT_PUBMED_24019758}}
 
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==Function==
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==NMR structure of RelA-TAD/CBP-TAZ1 complex==
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[[http://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>
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<StructureSection load='2lww' size='340' side='right'caption='[[2lww]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lww OCA], [https://pdbe.org/2lww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lww RCSB], [https://www.ebi.ac.uk/pdbsum/2lww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lww ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>
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==About this Structure==
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==See Also==
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[[2lww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWW OCA].
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*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024019758</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Histone acetyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ghosh, G.]]
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[[Category: Ghosh G]]
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[[Category: Mukherjee, S P.]]
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[[Category: Mukherjee SP]]
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[[Category: Wright, P E.]]
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[[Category: Wright PE]]
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[[Category: Nf-kappab]]
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[[Category: P65]]
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[[Category: Transcription]]
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Current revision

NMR structure of RelA-TAD/CBP-TAZ1 complex

PDB ID 2lww

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