4lt5

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'''Unreleased structure'''
 
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The entry 4lt5 is ON HOLD until Paper Publication
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==Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA==
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<StructureSection load='4lt5' size='340' side='right'caption='[[4lt5]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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Authors: Hashimoto, H., Pais, J.E., Zhang, X., Saleh, L., Fu, Z.Q., Dai, N., Correa, I.R., Roberts, R.J., Zheng, Y., Cheng, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lt5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naegleria_gruberi Naegleria gruberi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LT5 FirstGlance]. <br>
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Description: Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.893&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lt5 OCA], [https://pdbe.org/4lt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lt5 RCSB], [https://www.ebi.ac.uk/pdbsum/4lt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lt5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TET1_NAEGR TET1_NAEGR] Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and thereby plays a role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).<ref>PMID:24390346</ref> <ref>PMID:26323320</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Naegleria gruberi]]
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[[Category: Cheng X]]
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[[Category: Correa IR]]
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[[Category: Dai N]]
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[[Category: Fu ZQ]]
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[[Category: Hashimoto H]]
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[[Category: Pais JE]]
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[[Category: Roberts RJ]]
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[[Category: Saleh L]]
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[[Category: Zhang X]]
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[[Category: Zheng Y]]

Current revision

Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

PDB ID 4lt5

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