2o86

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[[Image:2o86.gif|left|200px]]<br /><applet load="2o86" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2o86, resolution 2.80&Aring;" />
 
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'''Crystal structure of a ternary complex of buffalo lactoperoxidase with nitrate and iodide at 2.8 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of a ternary complex of buffalo lactoperoxidase with nitrate and iodide at 2.8 A resolution==
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2O86 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=IOD:'>IOD</scene>, <scene name='pdbligand=NO3:'>NO3</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O86 OCA].
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<StructureSection load='2o86' size='340' side='right'caption='[[2o86]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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[[Category: Bubalus bubalis]]
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== Structural highlights ==
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[[Category: Peroxidase]]
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<table><tr><td colspan='2'>[[2o86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O86 FirstGlance]. <br>
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[[Category: Protein complex]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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[[Category: Kaur, P.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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[[Category: Sharma, S.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o86 OCA], [https://pdbe.org/2o86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o86 RCSB], [https://www.ebi.ac.uk/pdbsum/2o86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o86 ProSAT]</span></td></tr>
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[[Category: Sheikh, I A.]]
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</table>
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[[Category: Singh, A K.]]
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== Function ==
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[[Category: Singh, N.]]
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[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
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[[Category: Singh, T P.]]
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== Evolutionary Conservation ==
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[[Category: CA]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: CO3]]
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Check<jmol>
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[[Category: HEM]]
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<jmolCheckbox>
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[[Category: IOD]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/2o86_consurf.spt"</scriptWhenChecked>
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[[Category: NO3]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: anions]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: heme]]
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</jmolCheckbox>
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[[Category: peroxidase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o86 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:15:36 2008''
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==See Also==
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*[[Lactoperoxidase|Lactoperoxidase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bubalus bubalis]]
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[[Category: Large Structures]]
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[[Category: Kaur P]]
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[[Category: Sharma S]]
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[[Category: Sheikh IA]]
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[[Category: Singh AK]]
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[[Category: Singh N]]
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[[Category: Singh TP]]

Current revision

Crystal structure of a ternary complex of buffalo lactoperoxidase with nitrate and iodide at 2.8 A resolution

PDB ID 2o86

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