2o8w

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[[Image:2o8w.jpg|left|200px]]<br /><applet load="2o8w" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2o8w, resolution 1.86&Aring;" />
 
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'''Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors'''<br />
 
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==About this Structure==
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==Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors==
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2O8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=PG4:'>PG4</scene> and <scene name='pdbligand=PL0:'>PL0</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA].
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<StructureSection load='2o8w' size='340' side='right'caption='[[2o8w]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2o8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8W FirstGlance]. <br>
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[[Category: U-plasminogen activator]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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[[Category: Huang, M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PL0:1-PHENYLGUANIDINE'>PL0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Huang, Z.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8w OCA], [https://pdbe.org/2o8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8w RCSB], [https://www.ebi.ac.uk/pdbsum/2o8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8w ProSAT]</span></td></tr>
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[[Category: Jiang, L.]]
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</table>
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[[Category: Yuan, C.]]
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== Disease ==
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[[Category: Zhao, G.]]
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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[[Category: PG4]]
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== Function ==
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[[Category: PL0]]
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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[[Category: SO4]]
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== Evolutionary Conservation ==
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[[Category: benzamidine]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: contact area]]
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Check<jmol>
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[[Category: hydrolase]]
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<jmolCheckbox>
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[[Category: phenylguanidine]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/2o8w_consurf.spt"</scriptWhenChecked>
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[[Category: urokinase-type plasminogen activator]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o8w ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:15:45 2008''
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang M]]
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[[Category: Huang Z]]
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[[Category: Jiang L]]
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[[Category: Yuan C]]
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[[Category: Zhao G]]

Current revision

Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors

PDB ID 2o8w

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