4lc7

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{{STRUCTURE_4lc7| PDB=4lc7 | SCENE= }}
 
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===Aminooxazoline inhibitor of BACE-1===
 
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==Function==
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==Aminooxazoline inhibitor of BACE-1==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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<StructureSection load='4lc7' size='340' side='right'caption='[[4lc7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LC7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WP:(3AR,7AR)-3A-[3-(5-CHLOROPYRIDIN-3-YL)PHENYL]-3A,4,5,6,7,7A-HEXAHYDRO-1,3-BENZOXAZOL-2-AMINE'>1WP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lc7 OCA], [https://pdbe.org/4lc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lc7 RCSB], [https://www.ebi.ac.uk/pdbsum/4lc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lc7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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==About this Structure==
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==See Also==
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[[4lc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC7 OCA].
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Dutcher, D.]]
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[[Category: Dutcher D]]
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[[Category: Huestis, M P.]]
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[[Category: Huestis MP]]
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[[Category: Hunt, K W.]]
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[[Category: Hunt KW]]
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[[Category: Liu, W.]]
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[[Category: Liu W]]
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[[Category: Purkey, H E.]]
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[[Category: Purkey HE]]
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[[Category: Siu, M.]]
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[[Category: Siu M]]
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[[Category: Smith, D.]]
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[[Category: Smith D]]
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[[Category: Vigers, G P.A.]]
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[[Category: Vigers GPA]]
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[[Category: Volgraf, M.]]
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[[Category: Volgraf M]]
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[[Category: Wang, W.]]
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[[Category: Wang W]]
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[[Category: Wu, C.]]
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[[Category: Wu C]]
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[[Category: Aspartyl protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Aminooxazoline inhibitor of BACE-1

PDB ID 4lc7

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