4mbs

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{{STRUCTURE_4mbs| PDB=4mbs | SCENE= }}
 
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===Crystal Structure of the CCR5 Chemokine Receptor===
 
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{{ABSTRACT_PUBMED_24030490}}
 
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==Disease==
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==Crystal Structure of the CCR5 Chemokine Receptor==
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[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
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<StructureSection load='4mbs' size='340' side='right'caption='[[4mbs]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRV:4,4-DIFLUORO-N-[(1S)-3-{(3-EXO)-3-[3-METHYL-5-(PROPAN-2-YL)-4H-1,2,4-TRIAZOL-4-YL]-8-AZABICYCLO[3.2.1]OCT-8-YL}-1-PHENYLPROPYL]CYCLOHEXANECARBOXAMIDE'>MRV</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbs OCA], [https://pdbe.org/4mbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbs RCSB], [https://www.ebi.ac.uk/pdbsum/4mbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbs ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[https://omim.org/entry/612522 612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref> [https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc. The structure reveals a ligand-binding site that is distinct from the proposed major recognition sites for chemokines and the viral glycoprotein gp120, providing insights into the mechanism of allosteric inhibition of chemokine signaling and viral entry. A comparison between CCR5 and CXCR4 crystal structures, along with models of co-receptor-gp120-V3 complexes, suggests that different charge distributions and steric hindrances caused by residue substitutions may be major determinants of HIV-1 co-receptor selectivity. These high-resolution insights into CCR5 can enable structure-based drug discovery for the treatment of HIV-1 infection.
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==Function==
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Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.,Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, Liu H, Stevens RC, Zhao Q, Wu B Science. 2013 Sep 20;341(6152):1387-90. doi: 10.1126/science.1241475. Epub 2013, Sep 12. PMID:24030490<ref>PMID:24030490</ref>
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[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4mbs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA].
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</div>
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<div class="pdbe-citations 4mbs" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:024030490</ref><references group="xtra"/><references/>
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<references/>
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[[Category: Cherezov, V.]]
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__TOC__
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[[Category: Fenalti, G.]]
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</StructureSection>
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[[Category: GPCR, GPCR Network.]]
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[[Category: Clostridium pasteurianum]]
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[[Category: Han, G W.]]
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[[Category: Homo sapiens]]
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[[Category: Li, J.]]
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[[Category: Large Structures]]
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[[Category: Liu, H.]]
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[[Category: Cherezov V]]
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[[Category: Stevens, R C.]]
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[[Category: Fenalti G]]
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[[Category: Tan, Q.]]
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[[Category: Han GW]]
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[[Category: Wu, B.]]
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[[Category: Li J]]
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[[Category: Zhao, Q.]]
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[[Category: Liu H]]
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[[Category: Zhu, Y.]]
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[[Category: Stevens RC]]
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[[Category: Anti-hiv agent]]
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[[Category: Tan Q]]
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[[Category: G protein-coupled receptor]]
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[[Category: Wu B]]
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[[Category: Gpcr network]]
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[[Category: Zhao Q]]
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[[Category: Human ccr5 chemokine receptor]]
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[[Category: Zhu Y]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Seven transmembrane helice]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Crystal Structure of the CCR5 Chemokine Receptor

PDB ID 4mbs

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