4m6p

{{STRUCTURE_4m6p| PDB=4m6p | SCENE= }}

===Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===

{{ABSTRACT_PUBMED_24021463}}

==Function==

[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

==About this Structure==

[[4m6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6P OCA].

 

<ref group="xtra">PMID:024021463</ref><references group="xtra"/><references/>

[[Category: Nicotinamide phosphoribosyltransferase]]

[[Category: Bravo, B.]]

[[Category: Brien, T O.]]

[[Category: Dragovich, P S.]]

[[Category: Feng, Y.]]

[[Category: Giannetti, A M.]]

[[Category: Gunzner-Toste, J.]]

[[Category: Ho, Y.]]

[[Category: Hua, R.]]

[[Category: Liederer, B M.]]

[[Category: Liu, Y.]]

[[Category: Oeh, J.]]

[[Category: Sampath, D.]]

[[Category: Shen, Y.]]

[[Category: Skelton, N.]]

[[Category: Wang, C.]]

[[Category: Wang, L.]]

[[Category: Wang, W.]]

[[Category: Wu, H.]]

[[Category: Xiao, Y.]]

[[Category: Yuen, P.]]

[[Category: Zak, M.]]

[[Category: Zhao, G.]]

[[Category: Zhao, Q.]]

[[Category: Zheng, X.]]

[[Category: Transferase-transferase inhibitor complex]]