4h2a

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{{STRUCTURE_4h2a| PDB=4h2a | SCENE= }}
 
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===Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)===
 
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==Function==
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==Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)==
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[[http://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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<StructureSection load='4h2a' size='340' side='right'caption='[[4h2a]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4h2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H2A FirstGlance]. <br>
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[[4h2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2A OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2a OCA], [https://pdbe.org/4h2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h2a RCSB], [https://www.ebi.ac.uk/pdbsum/4h2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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__TOC__
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Baker, P J.]]
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[[Category: Large Structures]]
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[[Category: Sorrell, F J.]]
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[[Category: Baker PJ]]
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[[Category: Extracellular region]]
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[[Category: Sorrell FJ]]
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[[Category: Metal ion binding]]
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[[Category: Protein binding]]
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[[Category: Toxin]]
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[[Category: Toxin delivery]]
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Current revision

Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)

PDB ID 4h2a

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