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4jbx
From Proteopedia
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| - | {{STRUCTURE_4jbx| PDB=4jbx | SCENE= }} | ||
| - | ===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with SK-78=== | ||
| - | {{ABSTRACT_PUBMED_21623543}} | ||
| - | == | + | ==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with SK-78== |
| - | [[ | + | <StructureSection load='4jbx' size='340' side='right'caption='[[4jbx]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4jbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBX FirstGlance]. <br> |
| - | [[4jbx]] is a 2 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SK7:6-[3-HYDROXY-2-(HYDROXYMETHYL)PROP-1-EN-1-YL]-1,5-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>SK7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbx OCA], [https://pdbe.org/4jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbx RCSB], [https://www.ebi.ac.uk/pdbsum/4jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | ||
==See Also== | ==See Also== | ||
| - | *[[Thymidine kinase|Thymidine kinase]] | + | *[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human alphaherpesvirus 1 strain 17]] | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Novakovic | + | [[Category: Novakovic I]] |
| - | [[Category: Pernot | + | [[Category: Pernot L]] |
| - | [[Category: Perozzo | + | [[Category: Perozzo R]] |
| - | [[Category: Raic-Malic | + | [[Category: Raic-Malic S]] |
| - | [[Category: Scapozza | + | [[Category: Scapozza L]] |
| - | [[Category: Westermaier | + | [[Category: Westermaier Y]] |
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Current revision
Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with SK-78
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