4c00

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{{STRUCTURE_4c00| PDB=4c00 | SCENE= }}
 
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===Crystal structure of TamA from E. coli===
 
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{{ABSTRACT_PUBMED_24056943}}
 
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==Function==
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==Crystal structure of TamA from E. coli==
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[[http://www.uniprot.org/uniprot/TAMA_ECOLI TAMA_ECOLI]] Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear.<ref>PMID:22466966</ref>
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<StructureSection load='4c00' size='340' side='right'caption='[[4c00]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4c00]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C00 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c00 OCA], [https://pdbe.org/4c00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c00 RCSB], [https://www.ebi.ac.uk/pdbsum/4c00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c00 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TAMA_ECOLI TAMA_ECOLI] Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear.<ref>PMID:22466966</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TamA is an Escherichia coli Omp85 protein involved in autotransporter biogenesis. It comprises a 16-stranded transmembrane beta-barrel and three POTRA domains. The 2.3-A crystal structure reveals that the TamA barrel is closed at the extracellular face by a conserved lid loop. The C-terminal beta-strand of the barrel forms an unusual inward kink, which weakens the lateral barrel wall and creates a gate for substrate access to the lipid bilayer.
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==About this Structure==
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The structural basis of autotransporter translocation by TamA.,Gruss F, Zahringer F, Jakob RP, Burmann BM, Hiller S, Maier T Nat Struct Mol Biol. 2013 Sep 22. doi: 10.1038/nsmb.2689. PMID:24056943<ref>PMID:24056943</ref>
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[[4c00]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C00 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024056943</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4c00" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Burmann, B M.]]
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[[Category: Large Structures]]
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[[Category: Gruss, F.]]
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[[Category: Burmann BM]]
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[[Category: Hiller, S.]]
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[[Category: Gruss F]]
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[[Category: Jakob, R P.]]
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[[Category: Hiller S]]
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[[Category: Maier, T.]]
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[[Category: Jakob RP]]
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[[Category: Zaehringer, F.]]
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[[Category: Maier T]]
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[[Category: Autotransporter assembly]]
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[[Category: Zaehringer F]]
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[[Category: Autotransporter biogenesis]]
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[[Category: Outer membrane protein]]
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[[Category: Polypeptide transport-associated]]
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[[Category: Transport protein]]
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[[Category: Ytfm]]
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Current revision

Crystal structure of TamA from E. coli

PDB ID 4c00

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