4lku

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{{STRUCTURE_4lku| PDB=4lku | SCENE= }}
 
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===Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance===
 
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{{ABSTRACT_PUBMED_24038743}}
 
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==Function==
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==Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance==
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[[http://www.uniprot.org/uniprot/C9QXJ2_ECOD1 C9QXJ2_ECOD1]] Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity).[SAAS:SAAS001185_004_016395][HAMAP-Rule:MF_00115]
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<StructureSection load='4lku' size='340' side='right'caption='[[4lku]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lku]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH1 Escherichia coli DH1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LKU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lku OCA], [https://pdbe.org/4lku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lku RCSB], [https://www.ebi.ac.uk/pdbsum/4lku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lku ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSCL_ECOLI MSCL_ECOLI] Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. Participates in the regulation of osmotic pressure changes within the cell. Opens at a pressure just below that which would cause cell disruption and death. The force required to trigger channel opening depends on the membrane lipids composition.<ref>PMID:10202137</ref> <ref>PMID:23416054</ref> <ref>PMID:23875651</ref> <ref>PMID:7511799</ref> <ref>PMID:9632260</ref>
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==About this Structure==
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==See Also==
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[[4lku]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKU OCA].
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024038743</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Rees, D C.]]
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</StructureSection>
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[[Category: Walton, T A.]]
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[[Category: Escherichia coli DH1]]
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[[Category: Pentamer]]
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[[Category: Large Structures]]
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[[Category: Transport protein]]
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[[Category: Rees DC]]
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[[Category: Walton TA]]

Current revision

Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance

PDB ID 4lku

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