2oo7

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[[Image:2oo7.jpg|left|200px]]<br /><applet load="2oo7" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2oo7, resolution 1.800&Aring;" />
 
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'''Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R)'''<br />
 
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==About this Structure==
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==Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R)==
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2OO7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=AP5:'>AP5</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+920'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+B+921'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+B+922'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+A+923'>AC4</scene>, <scene name='pdbsite=AC5:Ap5+Binding+Site+For+Residue+A+1218'>AC5</scene> and <scene name='pdbsite=AC6:Ap5+Binding+Site+For+Residue+B+1219'>AC6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OO7 OCA].
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<StructureSection load='2oo7' size='340' side='right'caption='[[2oo7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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[[Category: Adenylate kinase]]
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== Structural highlights ==
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[[Category: Bacillus subtilis]]
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<table><tr><td colspan='2'>[[2oo7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OO7 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Counago, R.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Myers, J C.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oo7 OCA], [https://pdbe.org/2oo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2oo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oo7 ProSAT]</span></td></tr>
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[[Category: Shamoo, Y.]]
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</table>
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[[Category: Wilson, C J.]]
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== Function ==
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[[Category: Wittung-Stafshede, P.]]
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[https://www.uniprot.org/uniprot/KAD_BACSU KAD_BACSU] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth.
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[[Category: Wu, G.]]
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== Evolutionary Conservation ==
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[[Category: AP5]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: MG]]
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Check<jmol>
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[[Category: ZN]]
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<jmolCheckbox>
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[[Category: adenylate kinase]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oo7_consurf.spt"</scriptWhenChecked>
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[[Category: directed evolution]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: experimental adaptive evolution]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: thermostability]]
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</jmolCheckbox>
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[[Category: transferase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oo7 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:41 2008''
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==See Also==
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Bacillus subtilis]]
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[[Category: Large Structures]]
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[[Category: Counago R]]
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[[Category: Myers JC]]
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[[Category: Shamoo Y]]
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[[Category: Wilson CJ]]
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[[Category: Wittung-Stafshede P]]
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[[Category: Wu G]]

Current revision

Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R)

PDB ID 2oo7

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