This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2op7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:21, 28 December 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2op7.jpg|left|200px]]<br /><applet load="2op7" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2op7" />
 
-
'''WW4'''<br />
 
-
==About this Structure==
+
==WW4==
-
2OP7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OP7 OCA].
+
<StructureSection load='2op7' size='340' side='right'caption='[[2op7]]' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2op7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OP7 FirstGlance]. <br>
-
[[Category: Ahmed, S.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
[[Category: Li, M F.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2op7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2op7 OCA], [https://pdbe.org/2op7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2op7 RCSB], [https://www.ebi.ac.uk/pdbsum/2op7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2op7 ProSAT]</span></td></tr>
-
[[Category: Pu, H.]]
+
</table>
-
[[Category: Qin, H N.]]
+
== Function ==
-
[[Category: Sankaran, S.]]
+
[https://www.uniprot.org/uniprot/WWP1_HUMAN WWP1_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.<ref>PMID:15359284</ref> <ref>PMID:15221015</ref> <ref>PMID:12535537</ref>
-
[[Category: Song, J X.]]
+
== Evolutionary Conservation ==
-
[[Category: beta sheet]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: ligase]]
+
Check<jmol>
-
[[Category: ww domain]]
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2op7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2op7 ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:58 2008''
+
==See Also==
 +
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Ahmed S]]
 +
[[Category: Li MF]]
 +
[[Category: Pu H]]
 +
[[Category: Qin HN]]
 +
[[Category: Sankaran S]]
 +
[[Category: Song JX]]

Current revision

WW4

PDB ID 2op7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2op7"
Personal tools