2oss

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[[Image:2oss.gif|left|200px]]<br /><applet load="2oss" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2oss, resolution 1.350&Aring;" />
 
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'''Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 (BRD4)'''<br />
 
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==About this Structure==
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==Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 (BRD4)==
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2OSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSS OCA].
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<StructureSection load='2oss' size='340' side='right'caption='[[2oss]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2oss]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSS FirstGlance]. <br>
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[[Category: Arrowsmith, C H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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[[Category: Burgess, N.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Delft, F von.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oss OCA], [https://pdbe.org/2oss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oss RCSB], [https://www.ebi.ac.uk/pdbsum/2oss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oss ProSAT]</span></td></tr>
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[[Category: Edwards, A.]]
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</table>
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[[Category: Filippakopoulos, P.]]
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== Disease ==
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[[Category: Keates, T.]]
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[[Category: Knapp, S.]]
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== Function ==
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[[Category: Pike, A C.W.]]
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[[Category: SGC, Structural Genomics Consortium.]]
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== Evolutionary Conservation ==
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[[Category: Savitsky, P.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Sundstrom, M.]]
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Check<jmol>
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[[Category: Ugochukwu, E.]]
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<jmolCheckbox>
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[[Category: Weigelt, J.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2oss_consurf.spt"</scriptWhenChecked>
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[[Category: EDO]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: brd4]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: bromodomain containing protein 4]]
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</jmolCheckbox>
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[[Category: sgc]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oss ConSurf].
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[[Category: structural genomics consortium]]
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bromodomains (BRDs) are protein interaction modules that specifically recognize epsilon-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family.
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:22:05 2008''
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Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2oss" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Burgess N]]
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[[Category: Edwards A]]
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[[Category: Filippakopoulos P]]
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[[Category: Keates T]]
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[[Category: Knapp S]]
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[[Category: Pike ACW]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom M]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 (BRD4)

PDB ID 2oss

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OCA

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