4c99
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4c99 is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I== | |
| + | <StructureSection load='4c99' size='340' side='right'caption='[[4c99]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4c99]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C99 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c99 OCA], [https://pdbe.org/4c99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c99 RCSB], [https://www.ebi.ac.uk/pdbsum/4c99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c99 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Jones EY]] | ||
| + | [[Category: Zebisch M]] | ||
Current revision
Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I
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