3wgu

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{{STRUCTURE_3wgu| PDB=3wgu | SCENE= }}
 
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===Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin===
 
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==Function==
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==Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin==
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[[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
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<StructureSection load='3wgu' size='340' side='right'caption='[[3wgu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3wgu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WGU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wgu OCA], [https://pdbe.org/3wgu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wgu RCSB], [https://www.ebi.ac.uk/pdbsum/3wgu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wgu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
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==About this Structure==
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==See Also==
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[[3wgu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGU OCA].
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*[[ATPase 3D structures|ATPase 3D structures]]
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[[Category: Sodium/potassium-exchanging ATPase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Cornelius, F.]]
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[[Category: Cornelius F]]
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[[Category: Kanai, R.]]
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[[Category: Kanai R]]
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[[Category: Ogawa, H.]]
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[[Category: Ogawa H]]
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[[Category: Toyoshima, C.]]
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[[Category: Toyoshima C]]
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[[Category: Vilsen, B.]]
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[[Category: Vilsen B]]
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[[Category: Atp-binding]]
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[[Category: Atpase]]
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[[Category: Haloacid dehydrogenease superfamily]]
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[[Category: Hydrolase-transport protein complex]]
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[[Category: Ion pump]]
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[[Category: Ion transport]]
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[[Category: Membrane protein]]
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[[Category: Na+ binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphate analogue]]
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[[Category: Phosphoprotein]]
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Current revision

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin

PDB ID 3wgu

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