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2oxz

From Proteopedia

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[[Image:2oxz.jpg|left|200px]]<br /><applet load="2oxz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2oxz, resolution 1.90&Aring;" />
 
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'''Human MMP-12 in complex with two peptides PQG and IAG'''<br />
 
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==Disease==
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==Human MMP-12 in complex with two peptides PQG and IAG==
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Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]]
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<StructureSection load='2oxz' size='340' side='right'caption='[[2oxz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2oxz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OXZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oxz OCA], [https://pdbe.org/2oxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oxz RCSB], [https://www.ebi.ac.uk/pdbsum/2oxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oxz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ox/2oxz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oxz ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2OXZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXZ OCA].
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Snapshots of the reaction mechanism of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ, Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17096442 17096442]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Bertini I]]
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[[Category: Bertini, I.]]
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[[Category: Calderone V]]
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[[Category: Calderone, V.]]
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[[Category: Fragai M]]
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[[Category: Fragai, M.]]
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[[Category: Luchinat C]]
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[[Category: Luchinat, C.]]
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[[Category: Maletta M]]
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[[Category: Maletta, M.]]
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[[Category: Yeo KJ]]
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[[Category: Yeo, K J.]]
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[[Category: CA]]
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[[Category: ZN]]
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[[Category: matrix metalloproteinase]]
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[[Category: mmp-12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:50 2008''
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Current revision

Human MMP-12 in complex with two peptides PQG and IAG

PDB ID 2oxz

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