Ribosomal protein L1

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[[Image:RPL1.png|left|200px|thumb|Crystal Structure of Ribosomal protein L1 from ''Thermus thermophilus'' ([[2xg0]], chain C)]]
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<StructureSection load='4f9t' size='350' side='right' scene='' caption='Ribosomal protein L1 from Thermus thermophilus complex with MPD and sulfate (PDB code [[4f9t]])'>
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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=400| SCENE=Ribosomal_protein_L1/Cv/1 |right|CAPTION=Ribosomal protein L1 from ''Thermus thermophilus'' [[2xg0]], chain C }}
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[[Ribosomal protein L1]] (RPL1) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L1/Cv/3'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to 23S or 28S RRNA. In the archaea family it is named L1P. The images at the left and at the right correspond to one representative RPL1, ''i.e.'' the crystal structure of Ribosomal protein L1 from ''Thermus thermophilus'' ([[2xg0]], chain C).
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{{TOC limit|limit=2}}
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[[Ribosomal protein L1]] (RPL1) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L1/Cv/3'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to 23S or 28S RRNA<ref>PMID:15659579</ref>. In the archaea family it is named L1P.
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</StructureSection>
== 3D Structures of Ribosomal protein L1 ==
== 3D Structures of Ribosomal protein L1 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== RPL1 ===
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*Ribosomal protein L1
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[[2oum]], [[2ov7]] - TtRPL1 domain 1 – ''Thermus thermophilus''<br />
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[[4f9t]] – TtRPL1 <br />
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[[2hw8]], [[1zho]] - TtRPL1+mRNA fragment <br />
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[[1ad2]], [[3tg8]], [[3u42]] – TtRPL1 (mutant)<br />
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[[3u4m]], [[3u56]], [[3umy]] - TtRPL1 (mutant) + RNA<br />
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[[1u63]] - MjRPL1P+mRNA fragment – ''Methanocaldococcus jannaschii''<br />
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[[1i2a]], [[1cjs]] - MjRPL1P<br />
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[[1dwu]] - RPL1 – ''Methanococcus thermolithotrophicus''<br />
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[[3qoy]] – RPL1 – ''Aquifex aeolicus''<br />
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[[1mzp]] – RPL1P+23S RRNA fragment – ''Sulfolobus acidocaldarius''<br />
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[[2vpl]] - TtRPL1 residues 2-68 160-229+mRNA fragment <br />
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=== L1 in 50S subunit+RNA ===
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL1 in 50S subunit+RNA fragments <br />
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47]], [[2v49]], [[1vsa]], [[2hgj]], [[2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[3zvp]], [[3v6w]], [[3v6x]], [[3zn9]], [[3zne]], [[4b8g]], [[4b8i]], [[4btd]], [[4ejb]], [[4ejc]], [[4jux]], [[4k0m]], [[4k0q]], [[4kbu]], [[4kbw]], [[4kcz]], [[4kd2]], [[4kd9]], [[4kdb]], [[4kdh]], [[4kdk]] - TtRPL1 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fin]] - TtRPL1 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[2wwq]] – EcRPL1 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<br />
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[[3e1b]], [[3e1d]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]] - EcRPL1P in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fik]], [[2gya]], [[2gyc]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]] - EcRPL1 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[3kcr]], [[3j01]] - EcRPL1 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase - Cryo-EM<br />
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[[2rdo]] - EcRPL1 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<br />
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[[3bbo]] - RPL1 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
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[[3j21]] – RPL1 in 50S subunit – ''Pyrococcus furiosus''<br />
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[[3j3v]], [[3j3w]] - RPL1 in 50S subunit+5S RRNA+23S RRNA – ''Bacillus subtilis''<br />
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=== L1 in 60S subunit ===
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[[3jyw]] - RPL1 in 60S subunit – ''Thermomyces lanuginosus'' – Cryo-EM<br />
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[[3izr]], [[3izt]], [[3izu]], [[3izs]] - RPL1 in 60S subunit – wheat<br />
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[[2ftc]] - RPL1 in 60S subunit+16S RRNA - bovine<br />
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[[1s1h]], [[1s1i]] - yRPL1 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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[[3o58]], [[3o5h]] - yRPL1 in 60S ribosomal subunit+5.8S RRNA + 5S RRNA + 25S RRNA
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=== L1 in part of the large ribosomal subunit ===
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[[487d]] – TtRPL1+RPL2+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo-EM<br />
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[[2noq]] – yRPL1+RPL11+RPS5+18S RRNA+Cricket paralysis virus IRES RNA<br />
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=== L1 in large + small ribosomal subunit ===
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[[1ml5]] - EcRPL1 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM<br />
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=== L1 in 50S subunit + various proteins ===
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[[2om7]] – TtRPL1+RPS2+RPS12+tRNA+16S RRNA fragments+23S RRNA fragments+EF-G
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===L1 in 50S subunit + antibiotic ===
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**[[2oum]], [[2ov7]] - TtRPL1 domain 1 – ''Thermus thermophilus''<br />
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**[[4f9t]] – TtRPL1 <br />
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**[[1ad2]], [[3tg8]], [[4qgb]], [[4reo]] – TtRPL1 (mutant)<br />
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**[[2hw8]], [[1zho]] - TtRPL1+mRNA fragment <br />
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**[[5npm]] - TtRPL1 + 23S RNA <br />
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**[[3u4m]], [[3u56]], [[3umy]], [[4qg3]], [[4qvi]] - TtRPL1 (mutant) + RNA<br />
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**[[2vpl]] - TtRPL1 residues 2-68 160-229+mRNA fragment <br />
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**[[2om7]] – TtRPL1+RPS2+RPS12+tRNA+16S RRNA fragments+23S RRNA fragments+EF-G <br />
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**[[1u63]] - MjRPL1P+mRNA fragment – ''Methanocaldococcus jannaschii''<br />
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**[[1i2a]], [[1cjs]], [[4lq4]] - MjRPL1P<br />
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**[[1dwu]] - RPL1 – ''Methanococcus thermolithotrophicus''<br />
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**[[3qoy]] – RPL1 – ''Aquifex aeolicus''<br />
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**[[1mzp]] – RPL1P+23S RRNA fragment – ''Sulfolobus acidocaldarius''<br />
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[[3pio]], [[3pip]] - RPL1 in 50S subunit+5S RRNA+23SRRNA+antibiotic - ''Deinococcus radiodurans''<br />
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*Ribosomal protein L1 in part of the large ribosomal subunit
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**[[487d]] – TtRPL1+RPL2+RPL6+RPL9+RPL11+RPL14+RPL25 - Cryo-EM<br />
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**[[2noq]] – yRPL1+RPL11+RPS5+18S RRNA+Cricket paralysis virus IRES RNA<br />
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**[[3j5s]] - RPL1+RPL5+RPL33+RPS7+16S RRNA + 23S RRNA + p-site tRNA + ETTA – ''Escherichia coli'' - Cryo_EM<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L1 from Thermus thermophilus complex with MPD and sulfate (PDB code 4f9t)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L1

Updated on 19-December-2019

References

  1. ↑ Nevskaya N, Tishchenko S, Gabdoulkhakov A, Nikonova E, Nikonov O, Nikulin A, Platonova O, Garber M, Nikonov S, Piendl W. Ribosomal protein L1 recognizes the same specific structural motif in its target sites on the autoregulatory mRNA and 23S rRNA. Nucleic Acids Res. 2005 Jan 19;33(2):478-85. Print 2005. PMID:15659579 doi:33/2/478

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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