Ribosomal protein L7/L12

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[[Image:1dd3.png|left|200px|thumb|Crystal Structure of Ribosomal protein L7/L12 from ''Thermotoga maritima'' ([[1dd3]])]]
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<StructureSection load='1dd3' size='350' side='right' scene='' caption='Ribosomal protein L7/L12 (PDB code [[1dd3]])'>
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{{STRUCTURE_1dd3| PDB=1dd3 | SIZE=400| SCENE=Ribosomal_protein_L7/Cv/1 |right|CAPTION=Ribosomal protein L7/L12 from ''Thermotoga maritima'' [[1dd3]] }}
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== Function ==
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[[Ribosomal protein L7]] (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the '''L7/L12''' complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7<ref>PMID:23945946</ref>. In the archaea, the L7Ae acts as a subunit of RNase P.
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For more details see [[15.5kD/Snu13/L7Ae]].
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== Relevance ==
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RPL7 is an auto antigen in patients suffering from systemic lupus erythematosus and other connective tissue diseases<ref>PMID:7750987</ref>.
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</StructureSection>
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[[Ribosomal protein L7]] (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the L7/L12 complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7. In the archaea, the L7Ae acts as a subunit of RNase P.
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== 3D Structures of Ribosomal protein L7 ==
== 3D Structures of Ribosomal protein L7 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== RPL7 ===
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*Ribosomal protein L7
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[[1rqu]], [[1rqv]] - EcRPL7 - ''Escherichia coli'' - NMR<br />
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[[1dd3]], [[1dd4]] - TmRPL7/L12 - ''Thermotoga maritima''<br />
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[[1rqs]] – EcRPL7/L12 - NMR<br />
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[[1rqt]] - EcRPL7/L12 N-terminal – NMR<br />
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[[1ctf]] - EcRPL7/L12 C-terminal <br />
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[[3paf]] - MjRPL7Ae (mutant)<br />
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[[1ra4]], 1xbi – MjRPL7Ae – ''Methasnocaldococcus jannaschii''<br />
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[[1sds]] – MjRPL7Ae+box H/ACA RNA<br />
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[[2fc3]] – RPL7Ae – ''Aeropyrum pernix''<br />
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[[2czw]] – RPL7Ae – ''Pyrococcus horikoshii''<br />
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[[1pxw]] - RPL7Ae – ''Pyrococcus abyssi''<br />
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[[1rlg]] – RPL7Ae+RNA fragment – ''Archaeoglobus fulgidus''<br />
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[[3pla]] - RPL7Ae + pre mRNA splicing protein + fibrillarin-like methyltransferase + RNA - ''Sulfolobus solfataricus''<br />
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[[3o85]] - RPL7Ae – ''Giardia lamblia''<br />
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[[3nvi]] – PfRPL7Ae + NOP5/NOP56 + RNA – ''Pyrococcus furiosus''<br />
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[[3nvk]] – PfRPL7Ae + NOP5/NOP56 + fibrillarin-like methyltransferase + RNA
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=== L7 in 50S subunit+RNA ===
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[[2j01]], [[2j03]], [[1yl3]], [[3i8i]], [[1giy]], [[4kbu]], [[4kbw]], [[4kcz]], [[4kd2]], [[4kd9]], [[4kdb]], [[4kdh]], [[4kdk]] - TtRPL7 in 50S subunit+5S RRNA+23S RRNA<br />
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[[2gya]], [[2gyc]], [[4kix]] - EcRPL7 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[3uos]], [[3sgf]] - EcRPL7 in 50S subunit+5S RRNA+23S RRNA<br />
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[[2zjq]], [[2zjr]] - DrRPL7 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
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[[1kqs]], [[2qa4]], [[1qvg]] - HmRPL7 in 50S subunit+5S RRNA+23S RRNA+CCA - ''Haloarcula marismortui''<br />
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[[1jj2]], [[1ffk]], [[3cc2]], [[1s72]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA<br />
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[[1vqm]], [[1vql]], [[1vq7]], [[1vq4]], [[1vq5]], [[1vqp]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+transition state analogue<br />
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA (mutant)<br />
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[[1yj9]] - HmRPL7Ae in 50S subunit (mutant)+5S RRNA+23S RRNA<br />
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[[3cma]], [[3cme]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCA+CCA-Phe-CAP-BIO<br />
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[[1vq6]], [[1vqn]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+C-hpmn+CCA-Phe-CAP-BIO<br />
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[[1vqk]], [[1q86]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCDA-Phe-CAP-BIO<br />
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[[1vqo]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCPMN<br />
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[[1qvf]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+deacylated tRNA minihelix
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=== L7 in 50S subunit + antibiotics ===
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[[3cxc]] – RPL7Ae in 50S subunit+5S RRNA+23S RRNA +oxazolidinone inhibitor – ''Halobacterium marismortui''<br />
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[3qex]], [[3cpw]], [[3cc4]], [[2otj]], [[2otl]], [[1yit]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]], [[1nji]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+antibiotic <br />
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[[1m90]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin<br />
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[[3cd6]], [[1yhq]], [[1yi2]], [[1yij]], [[1yjn]], [[1yjw]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic<br />
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[[1vq8]], [[1vq9]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCDA-Phe-CAP-BIO+sparsomycin<br />
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=== L7 in 60S subunit ===
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[[3jyw]] - RPL7 in 60S subunit – ''Thermomyces lanuginosus'' – Cryo-EM<br />
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[[3izr]] – RPL7 in 60S subunit – wheat – Cryo-EM<br />
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[[3j39]] – RPL7 in 60S subunit – ''Drosophila melanogaster'' – Cryo-EM<br />
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[[3j3b]] – RPL7 in 60S subunit – human – Cryo-EM<br />
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[[3o58]], [[3o5h]] – yRPL7 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA<br />
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[[3izs]] – yRPL7 in 60S ribosomal subunit – yeast - Cryo-EM<br />
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[[3u5e]], [[3u5i]] – yRPL7 in 60S ribosomal subunit<br />
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[[4b6a]] - yRPL7 in 60S ribosomal subunit + P0 + P1 +P2 + ARX1 - Cryo-EM
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=== L7 in large + small ribosomal subunit ===
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[[2zkr]] - RPL7 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM – dog
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=== L7 in 50S subunit + various proteins ===
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[[1w2b]] - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal <br />
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[[3lwo]], [[3lwp]], [[3lwq]], [[3lwr]], [[3lwv]], [[3hax]], [[3hay]], [[3hjw]] – PfRPL7Ae+pseudouridine synthase+ribosome biogenesis protein NOP10+H/ACA RNA+RNA fragment <br />
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[[2hvy]] - PfRPL7Ae+pseudouridine synthase+ribosome biogenesis protein NOP10+H/ACA RNA+small nucleolar RNP<br />
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[[3nmu]] - PfRPL7Ae + NOP5 related protein + RNA + fibrillarin-like methyltransferase<br />
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[[3id5]] – SsRPL7Ae+pre RNA splicing protein+fibrillarin+half C/D RNA – ''Sulfolobus solfataricus''
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=== L7 in part of 50S subunit ===
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**[[1rqu]], [[1rqv]] - EcRPL7 - ''Escherichia coli'' - NMR<br />
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**[[1dd3]], [[1dd4]] - TmRPL7/L12 - ''Thermotoga maritima''<br />
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**[[1rqs]] – EcRPL7/L12 - NMR<br />
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**[[1rqt]] - EcRPL7/L12 N-terminal – NMR<br />
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**[[1ctf]] - EcRPL7/L12 C-terminal <br />
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**[[3paf]] - MjRPL7Ae (mutant)<br />
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**[[1ra4]], 1xbi – MjRPL7Ae – ''Methasnocaldococcus jannaschii''<br />
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**[[1sds]] – MjRPL7Ae+box H/ACA RNA<br />
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**[[2fc3]] – RPL7Ae – ''Aeropyrum pernix''<br />
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**[[2czw]] – RPL7Ae – ''Pyrococcus horikoshii''<br />
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**[[1pxw]] - RPL7Ae – ''Pyrococcus abyssi''<br />
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**[[1rlg]] – RPL7Ae+RNA fragment – ''Archaeoglobus fulgidus''<br />
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**[[3pla]] - RPL7Ae + pre mRNA splicing protein + fibrillarin-like methyltransferase + RNA - ''Sulfolobus solfataricus''<br />
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**[[3o85]] - RPL7Ae – ''Giardia lamblia''<br />
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**[[3nvi]] – PfRPL7Ae + NOP5/NOP56 + RNA – ''Pyrococcus furiosus''<br />
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**[[3nvk]] – PfRPL7Ae + NOP5/NOP56 + fibrillarin-like methyltransferase + RNA
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[[2bcw]] – EcRPL7/L12+EcRPL11+EF-G<br />
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*Ribosomal protein L7 in part of 50S subunit
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[[1zav]], [[1zaw]], [[1zax]] - TmRPL7/L12 N-terminal +RPL10
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**[[2bcw]] – EcRPL7/L12+EcRPL11+EF-G<br />
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**[[1zav]], [[1zaw]], [[1zax]] - TmRPL7/L12 N-terminal +RPL10
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L7/L12 (PDB code 1dd3)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L7

Updated on 05-January-2020

References

  1. ↑ Babiano R, Badis G, Saveanu C, Namane A, Doyen A, Diaz-Quintana A, Jacquier A, Fromont-Racine M, de la Cruz J. Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles. Nucleic Acids Res. 2013 Nov;41(20):9461-70. doi: 10.1093/nar/gkt726. Epub 2013, Aug 13. PMID:23945946 doi:http://dx.doi.org/10.1093/nar/gkt726
  2. ↑ von Mikecz A, Hemmerich P, Peter HH, Krawinkel U. Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. Immunobiology. 1994 Dec;192(1-2):137-54. PMID:7750987 doi:http://dx.doi.org/10.1016/S0171-2985(11)80413-4

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