4bnd

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{{STRUCTURE_4bnd| PDB=4bnd | SCENE= }}
 
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===Structure of an atypical alpha-phosphoglucomutase similar to eukaryotic phosphomannomutases===
 
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{{ABSTRACT_PUBMED_24100319}}
 
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==About this Structure==
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==Structure of an atypical alpha-phosphoglucomutase similar to eukaryotic phosphomannomutases==
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[[4bnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_mg1363 Lactococcus lactis subsp. cremoris mg1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BND OCA].
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<StructureSection load='4bnd' size='340' side='right'caption='[[4bnd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_MG1363 Lactococcus lactis subsp. cremoris MG1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BND FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bnd OCA], [https://pdbe.org/4bnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bnd RCSB], [https://www.ebi.ac.uk/pdbsum/4bnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bnd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A2RIP9_LACLM A2RIP9_LACLM]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The first structure of a bacterial alpha-phosphoglucomutase with an overall fold similar to eukaryotic phosphomannomutases is reported. Unlike most alpha-phosphoglucomutases within the alpha-D-phosphohexomutase superfamily, it belongs to subclass IIb of the haloacid dehalogenase superfamily (HADSF). It catalyzes the reversible conversion of alpha-glucose 1-phosphate to glucose 6-phosphate. The crystal structure of alpha-phosphoglucomutase from Lactococcus lactis (APGM) was determined at 1.5 A resolution and contains a sulfate and a glycerol bound at the enzyme active site that partially mimic the substrate. A dimeric form of APGM is present in the crystal and in solution, an arrangement that may be functionally relevant. The catalytic mechanism of APGM and its strict specificity towards alpha-glucose 1-phosphate are discussed.
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==Reference==
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High-resolution structure of an atypical alpha-phosphoglucomutase related to eukaryotic phosphomannomutases.,Nogly P, Matias PM, de Rosa M, Castro R, Santos H, Neves AR, Archer M Acta Crystallogr D Biol Crystallogr. 2013 Oct 1;69(Pt 10):2008-2016. Epub 2013, Sep 20. PMID:24100319<ref>PMID:24100319</ref>
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<ref group="xtra">PMID:024100319</ref><references group="xtra"/><references/>
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[[Category: Lactococcus lactis subsp. cremoris mg1363]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Phosphoglucomutase]]
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</div>
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[[Category: Archer, M.]]
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<div class="pdbe-citations 4bnd" style="background-color:#fffaf0;"></div>
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[[Category: Castro, R.]]
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== References ==
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[[Category: Matias, P M.]]
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<references/>
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[[Category: Neves, A R.]]
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__TOC__
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[[Category: Nogly, P.]]
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</StructureSection>
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[[Category: Rosa, M De.]]
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[[Category: Lactococcus lactis subsp. cremoris MG1363]]
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[[Category: Santos, H.]]
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[[Category: Large Structures]]
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[[Category: Isomerase]]
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[[Category: Archer M]]
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[[Category: Phosphoglucose interconversion]]
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[[Category: Castro R]]
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[[Category: Substrate specificity]]
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[[Category: De Rosa M]]
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[[Category: Matias PM]]
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[[Category: Neves AR]]
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[[Category: Nogly P]]
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[[Category: Santos H]]

Current revision

Structure of an atypical alpha-phosphoglucomutase similar to eukaryotic phosphomannomutases

PDB ID 4bnd

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