4n5q
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4n5q is ON HOLD Authors: Shi, D. J., Ye, S., Cao, X., Wang, K. W., Zhang, R. Description: Crystal structure of the N-terminal ankyrin repeat domain...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the N-terminal ankyrin repeat domain of TRPV3== | |
| + | <StructureSection load='4n5q' size='340' side='right'caption='[[4n5q]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4n5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.946Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5q OCA], [https://pdbe.org/4n5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5q RCSB], [https://www.ebi.ac.uk/pdbsum/4n5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Ion channels 3D structures|Ion channels 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Cao X]] | ||
| + | [[Category: Shi DJ]] | ||
| + | [[Category: Wang KW]] | ||
| + | [[Category: Ye S]] | ||
| + | [[Category: Zhang R]] | ||
Current revision
Crystal structure of the N-terminal ankyrin repeat domain of TRPV3
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Categories: Large Structures | Mus musculus | Cao X | Shi DJ | Wang KW | Ye S | Zhang R
