Ribosomal protein L3

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[[Image:RPL3.png|left|200px|thumb|Crystal Structure of Ribosomal protein L3 from ''Thermus thermophilus'' ([[2xg0]], chain E)]]
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<StructureSection load='' size='350' side='right' scene='Ribosomal_protein_L3/Cv/1' caption='Ribosomal protein L3 complex with 23S RNA and antibacterial drug (PDB code [[2ogm]])'>
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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=400| SCENE=Ribosomal_protein_L3/Cv/2 |right|CAPTION=Ribosomal protein L3 from ''Thermus thermophilus'' [[2xg0]], chain E }}
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== Function ==
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[[Ribosomal protein L3]] (RPL3 ) is one of the 34 proteins which belong to the <scene name='42/425998/Cv/4'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA near the 3'-end where it nucleates the assembly of the large subunit<ref>PMID:17194937</ref>. In the archaea like in ''Haloarcula marismortui'' the L3 is called L3P (RPL3P).
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[[Ribosomal protein L3]] (RPL3 ) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L3/Cv/3'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA near the 3'-end where it nucleates the assembly of the large subunit. In the archaea like in ''Haloarcula marismortui'' the L3 is called L3P (RPL3P). The images at the left and at the right correspond to one representative RPL3, ''i.e.'' the crystal structure of Ribosomal protein L3 from ''Thermus thermophilus'' ([[2xg0]], chain E).
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{{TOC limit|limit=2}}
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== Relevance ==
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Mutations in RPL3 are associated with reduced susceptibility to the antibiotic tiamulin<ref>PMID:15554969</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein L3 ==
== 3D Structures of Ribosomal protein L3 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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=== L3 in 50S subunit+RNA ===
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[[2ogm]], [[2ogn]], [[2ogo]] – RPL3 + 23S RRNA + antibiotic – ''Deinococcus radiodurans''<br />
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== References ==
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL3 in 50S subunit+RNA fragments – ''Thermus thermophilus''<br />
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<references/>
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47]], [[2v49]], [[1vsa]], [[2hgj]], [[2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[3tve]], [[3tvh]], [[3uye]], [[3uyg]], [[3uz1]], [[3uz2]], [[3uz8]], [[3uz9]], [[3uzf]], [[3uzh]], [[3uzk]], [[3uzn]], [[4dha]], [[4dhc]], [[3v23]], [[3v25]], [[3v27]], [[3v29]], [[3v2d]], [[3v2f]], [[3zvp]], [[3v6w]], [[3v6x]], [[3zn9]], [[3zne]], [[4b8g]], [[4b8i]], [[4btd]], [[4ejb]], [[4ejc]], [[4g5l]], [[4g5n]], [[4g5u]], [[4g5w]], [[4jux]], [[4k0m]], [[4k0q]], [[4kbu]], [[4kbw]], [[4kcz]], [[4kd2]], [[4kd9]], [[4kdb]], [[4kdh]], [[4kdk]], [[4kfi]], [[4kfl]] - TtRPL3 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fin]] - TtRPL3 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[2wwq]] – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<br />
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3ofd]], [[3og0]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]],[[3r8s]], [[3r8t]], [[3uos]], [[3uxq]], [[3uxr]], [[3sgf]], [[3j37]], [[4kix]], [[4kiz]], [[4kj1]], [[4kj3]], [[4kj5]], [[4kj7]], [[4kj9]], [[4kjb]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]],[[3izt]], [[3izu]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]], [[3j19]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[3j01]] – EcRPL3 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase – Cryo-EM<br />
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[3kcr]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase<br />
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[[2rdo]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<br />
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[[3bbo]] - RPL3 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
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[[3iy9]] – RPL3 in 50S subunit – ''Leishmania taretolae''<br />
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[[2zjq]], [[2zjr]], [[1nkw]], [[4io9]], [[4ioa]], [[4ioc]] - DrRPL3 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
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[[1kqs]], [[1qvg]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+CCA - ''Haloarcula marismortui''<br />
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[[1jj2]], [[1ffk]], [[3cc2]], [[2qa4]], [[1s72]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA<br />
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA (mutant)<br />
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[[1vq4]], [[1vq5]], [[1vq7]], [[1vql]], [[1vqm]], [[1vqp]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+transition state analog<br />
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[[1vq6]], [[1vqk]], [[1vqn]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin<br />
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[[1vqo]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+ CCPMN<br />
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[[1yhq]], [[1yi2]], [[1yij]], [[1yjn]], [[1yjw]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic<br />
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[[1yj9]] - HmRPL3P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA<br />
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[[1qvf]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix<br />
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[[1q86]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin<br />
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[[3j21]] – RPL3 in 50S subunit – ''Pyrococcus furiosus''<br />
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[[3j3v]], [[3j3w]] - RPL3 in 50S subunit – ''Bacillus subtilis''<br />
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=== L3 in 50S subunit + antibiotics ===
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[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - DrRPL3 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[2ogm]], [[2ogn]], [[2ogo]] - DrRPL3+23S RRNA+pleuromutilin derivative<br />
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[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] – TtRPL3 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[2qam]], [[2qao]], [[2qoz]], [[2qp1]], [[2qba]], [[2qbc]], [[3ofc]], [[3ofz]], [[3ofq]], [[3ofr]], [[1vt2]], [[3orb]],[[3oas]], [[3oat]], [[4gar]], [[4gau]], [[4l6j]], [[4l6l]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[2qex]], [[3cpw]], [[3cc4]], [[3cd6]], [[2otj]], [[2otl]], [[1yit]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]], [[1nji]], [[3cxc]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+antibiotic - ''Halobacterium marismortui''<br />
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[[1m90]], [[3cma]], [[3cme]], [[1vq8]], [[1vq9]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
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=== L3 in 60S subunit ===
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[[3jyw]] - RPL3 in 60S subunit – ''Thermomyces lanuginosus'' – Cryo-EM<br />
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[[3izr]] – RPL3 in 60S subunit – wheat – Cryo-EM<br />
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[[3j39]] – RPL3 in 60S subunit – ''Drosophila melanogaster'' – Cryo-EM<br />
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[[2ftc]] - RPL3 in 60S subunit+16S RRNA - bovine<br />
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[[1s1i]] - yRPL3 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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[[3izs]] – yRPL3 in 60S ribosomal subunit – Cryo-EM<br />
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[[3u5e]], [[3u5i]] – yRPL3 in 60S ribosomal subunit<br />
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[[3o58]], [[3o5h]] – yRPL3 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA
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=== L3 in large + small ribosomal subunit ===
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[[1ml5]] - EcRPL3 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM<br />
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[[2zkr]] - RPL3 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM - dog
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=== L3 in 50S subunit + ribosome releasing factor (RRF) ===
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[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+RRF
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=== L3 in 50S subunit + various proteins ===
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[[2vhm]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
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[[2j28]] - EcRPL3 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<br />
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[[1w2b]] - HmRPL3P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
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===L3 in 60S subunit + various proteins===
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[[4b6a]] – yRPL3 in 60S subunit +25S RRNA+5SRRNA + P0 + P1 + P2 + ARX1
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L3 complex with 23S RNA and antibacterial drug (PDB code 2ogm)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L3

Updated on 01-October-2017

2ogm, 2ogn, 2ogo – RPL3 + 23S RRNA + antibiotic – Deinococcus radiodurans

References

  1. ↑ Petrov A, Meskauskas A, Dinman JD. Ribosomal protein L3: influence on ribosome structure and function. RNA Biol. 2004 May;1(1):59-65. Epub 2004 May 1. PMID:17194937
  2. ↑ Pringle M, Poehlsgaard J, Vester B, Long KS. Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates. Mol Microbiol. 2004 Dec;54(5):1295-306. PMID:15554969 doi:http://dx.doi.org/10.1111/j.1365-2958.2004.04373.x

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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