2pa1

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[[Image:2pa1.jpg|left|200px]]<br /><applet load="2pa1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2pa1, resolution 1.700&Aring;" />
 
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'''Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin'''<br />
 
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==About this Structure==
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==Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin==
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2PA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PA1 OCA].
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<StructureSection load='2pa1' size='340' side='right'caption='[[2pa1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2pa1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PA1 FirstGlance]. <br>
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[[Category: Arrowsmith, C H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Bunkoczi, G.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Burgess-Brown, N.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pa1 OCA], [https://pdbe.org/2pa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pa1 RCSB], [https://www.ebi.ac.uk/pdbsum/2pa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pa1 ProSAT]</span></td></tr>
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[[Category: Delft, F von.]]
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</table>
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[[Category: Doyle, D A.]]
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== Function ==
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[[Category: Edwards, A.]]
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[https://www.uniprot.org/uniprot/PDLI2_HUMAN PDLI2_HUMAN] Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
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[[Category: Elkins, J.]]
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== Evolutionary Conservation ==
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[[Category: Papagrigoriou, E.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Pike, A C.W.]]
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Check<jmol>
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[[Category: SGC, Structural Genomics Consortium.]]
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<jmolCheckbox>
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[[Category: Salah, E.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/2pa1_consurf.spt"</scriptWhenChecked>
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[[Category: Shrestha, L.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Sundstrom, M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Turnbull, A P.]]
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</jmolCheckbox>
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[[Category: Ugochukwu, E.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pa1 ConSurf].
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[[Category: Umeano, C.]]
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<div style="clear:both"></div>
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[[Category: Uppenberg, J.]]
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[[Category: Weigelt, J.]]
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[[Category: CL]]
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[[Category: pdz domain]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:27:33 2008''
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==See Also==
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*[[PDZ and LIM domain protein|PDZ and LIM domain protein]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi G]]
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[[Category: Burgess-Brown N]]
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[[Category: Doyle DA]]
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[[Category: Edwards A]]
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[[Category: Elkins J]]
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[[Category: Papagrigoriou E]]
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[[Category: Pike ACW]]
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[[Category: Salah E]]
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[[Category: Shrestha L]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull AP]]
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[[Category: Ugochukwu E]]
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[[Category: Umeano C]]
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[[Category: Uppenberg J]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin

PDB ID 2pa1

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