4n71

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(New page: '''Unreleased structure''' The entry 4n71 is ON HOLD Authors: Lingaraju, M., Boal, A.K., Yennawar, N. Description: X-Ray Crystal Structure of 2-Amino-1-HydroxyEthyl Phosphonate-bound P...)
Current revision (12:31, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4n71 is ON HOLD
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==X-Ray Crystal Structure of 2-amino-1-hydroxyethylphosphonate-bound PhnZ==
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<StructureSection load='4n71' size='340' side='right'caption='[[4n71]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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Authors: Lingaraju, M., Boal, A.K., Yennawar, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n71]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_bacterium_HF130_AEPn_1 Uncultured bacterium HF130_AEPn_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N71 FirstGlance]. <br>
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Description: X-Ray Crystal Structure of 2-Amino-1-HydroxyEthyl Phosphonate-bound PhnZ
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.984&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ODV:[(1R)-2-AMINO-1-HYDROXYETHYL]PHOSPHONIC+ACID'>ODV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n71 OCA], [https://pdbe.org/4n71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n71 RCSB], [https://www.ebi.ac.uk/pdbsum/4n71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n71 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHNZ_UNCHF PHNZ_UNCHF] Involved in the degradation of the organophosphonate 2-aminoethylphosphonic acid (2-AEP) (Probable). Catalyzes the cleavage of the carbon-phosphorus bond of (2-amino-1-hydroxyethyl)phosphonic acid to yield glycine and phosphate through an oxidative mechanism (PubMed:22564006, PubMed:24198335, PubMed:24706911). It reacts stereospecifically with the R-enantiomer of (2-amino-1-hydroxyethyl)phosphonic acid and is also able to use (R,R)-2-amino-1-hydroxypropylphosphonate as substrate (PubMed:24706911).<ref>PMID:22564006</ref> <ref>PMID:24198335</ref> <ref>PMID:24706911</ref> <ref>PMID:19788654</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Uncultured bacterium HF130_AEPn_1]]
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[[Category: Boal AK]]
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[[Category: Bollinger Jr JM]]
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[[Category: Krebs C]]
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[[Category: Lingaraju M]]
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[[Category: Pandelia M-E]]
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[[Category: Woersdoerfer B]]
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[[Category: Yennawar N]]

Current revision

X-Ray Crystal Structure of 2-amino-1-hydroxyethylphosphonate-bound PhnZ

PDB ID 4n71

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