4n78

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(New page: '''Unreleased structure''' The entry 4n78 is ON HOLD Authors: Chen, Z.C. Description: The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton)
Current revision (12:31, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4n78 is ON HOLD
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==The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton==
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<StructureSection load='4n78' size='340' side='right'caption='[[4n78]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n78]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N78 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n78 OCA], [https://pdbe.org/4n78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n78 RCSB], [https://www.ebi.ac.uk/pdbsum/4n78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n78 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Angelman syndrome.
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== Function ==
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[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
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Authors: Chen, Z.C.
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==See Also==
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*[[Wiskott-Aldrich syndrome protein|Wiskott-Aldrich syndrome protein]]
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Description: The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen ZC]]

Current revision

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

PDB ID 4n78

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