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4i5x

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{{STRUCTURE_4i5x| PDB=4i5x | SCENE= }}
 
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===Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid===
 
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{{ABSTRACT_PUBMED_24100137}}
 
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==Function==
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==Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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<StructureSection load='4i5x' size='340' side='right'caption='[[4i5x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I5X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLF:2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]+BENZOIC+ACID'>FLF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i5x OCA], [https://pdbe.org/4i5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i5x RCSB], [https://www.ebi.ac.uk/pdbsum/4i5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i5x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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==About this Structure==
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==See Also==
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[[4i5x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I5X OCA].
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*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, S.]]
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[[Category: Large Structures]]
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[[Category: Zhai, J.]]
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[[Category: Chen S]]
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[[Category: Zhang, H.]]
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[[Category: Zhai J]]
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[[Category: Zhang, L.]]
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[[Category: Zhang H]]
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[[Category: Zhao, Y.]]
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[[Category: Zhang L]]
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[[Category: Zheng, X.]]
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[[Category: Zhao Y]]
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[[Category: Aldo-keto reductase]]
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[[Category: Zheng X]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid

PDB ID 4i5x

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