4l74
From Proteopedia
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| - | {{STRUCTURE_4l74| PDB=4l74 | SCENE= }} | ||
| - | ===Ca2+-bound MthK RCK domain at 1.9 Angstrom with single ligand=== | ||
| - | == | + | ==Ca2+-bound MthK RCK domain at 1.9 Angstrom with single ligand== |
| - | [[http://www.uniprot.org/uniprot/MTHK_METTH MTHK_METTH | + | <StructureSection load='4l74' size='340' side='right'caption='[[4l74]], [[Resolution|resolution]] 1.84Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4l74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L74 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.841Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l74 OCA], [https://pdbe.org/4l74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l74 RCSB], [https://www.ebi.ac.uk/pdbsum/4l74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l74 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MTHK_METTH MTHK_METTH] Calcium-gated potassium channel. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ligand binding sites within proteins can interact by allosteric mechanisms to modulate binding affinities and control protein function. Here we present crystal structures of the regulator of K(+) conductance (RCK) domain from a K(+) channel, MthK, which reveal the structural basis of allosteric coupling between two Ca(2+) regulatory sites within the domain. Comparison of RCK domain crystal structures in a range of conformations and with different numbers of regulatory Ca(2+) ions bound, combined with complementary electrophysiological analysis of channel gating, suggests chemical interactions that are important for modulation of ligand binding and subsequent channel opening. | ||
| - | + | Structural basis of allosteric interactions among Ca(2+)-binding sites in a K(+) channel RCK domain.,Smith FJ, Pau VP, Cingolani G, Rothberg BS Nat Commun. 2013;4:2621. doi: 10.1038/ncomms3621. PMID:24126388<ref>PMID:24126388</ref> | |
| - | + | ||
| - | [[ | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 4l74" style="background-color:#fffaf0;"></div> | |
| - | + | ||
| - | [[Category: | + | ==See Also== |
| - | [[Category: | + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Methanothermobacter thermautotrophicus str. Delta H]] | ||
| + | [[Category: Cingolani G]] | ||
| + | [[Category: Rothberg BS]] | ||
| + | [[Category: Smith FJ]] | ||
Current revision
Ca2+-bound MthK RCK domain at 1.9 Angstrom with single ligand
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