2lna

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{{STRUCTURE_2lna| PDB=2lna | SCENE= }}
 
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===Solution NMR Structure of the mitochondrial inner membrane domain (residues 164-251), FtsH_ext, from the paraplegin-like protein AFG3L2 from Homo sapiens, Northeast Structural Genomics Consortium Target HR6741A===
 
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{{ABSTRACT_PUBMED_24055473}}
 
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==Disease==
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==Solution NMR Structure of the mitochondrial inner membrane domain (residues 164-251), FtsH_ext, from the paraplegin-like protein AFG3L2 from Homo sapiens, Northeast Structural Genomics Consortium Target HR6741A==
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[[http://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN]] Spinocerebellar ataxia type 28;Early-onset spastic ataxia-neuropathy syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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<StructureSection load='2lna' size='340' side='right'caption='[[2lna]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lna OCA], [https://pdbe.org/2lna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lna RCSB], [https://www.ebi.ac.uk/pdbsum/2lna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lna ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN] Spinocerebellar ataxia type 28;Early-onset spastic ataxia-neuropathy syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN] ATP-dependent protease which is essential for axonal development (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the solution NMR structure of the intermembrane space domain (IMSD) of the human mitochondrial ATPase associated with various activities (AAA) protease known as AFG3-like protein 2 (AFG3L2). Our structural analysis and molecular dynamics results indicate that the IMSD is peripherally bound to the membrane surface. This is a modification to the location of the six IMSDs in a model of the full length yeast hexaoligomeric homolog of AFG3L2 determined at low resolution by electron cryomicroscopy [1]. The predicted protein-protein interaction surface, located on the side furthest from the membrane, may mediate binding to substrates as well as prohibitins.
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==Function==
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NMR structure and MD simulations of the AAA protease intermembrane space domain indicates peripheral membrane localization within the hexaoligomer.,Ramelot TA, Yang Y, Sahu ID, Lee HW, Xiao R, Lorigan GA, Montelione GT, Kennedy MA FEBS Lett. 2013 Nov 1;587(21):3522-8. doi: 10.1016/j.febslet.2013.09.009. Epub, 2013 Sep 18. PMID:24055473<ref>PMID:24055473</ref>
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[[http://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN]] ATP-dependent protease which is essential for axonal development (By similarity).
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[2lna]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNA OCA].
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</div>
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<div class="pdbe-citations 2lna" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:024055473</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Everett, J K.]]
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[[Category: Acton TB]]
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[[Category: Janua, H.]]
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[[Category: Everett JK]]
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[[Category: Kennedy, M A.]]
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[[Category: Janua H]]
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[[Category: Kohan, E.]]
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[[Category: Kennedy MA]]
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[[Category: Lee, H.]]
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[[Category: Kohan E]]
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[[Category: MPP, Mitochondrial Protein Partnership.]]
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[[Category: Lee H]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione GT]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Prestegard JH]]
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[[Category: Prestegard, J H.]]
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[[Category: Ramelot TA]]
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[[Category: Ramelot, T A.]]
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[[Category: Shastry R]]
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[[Category: Shastry, R.]]
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[[Category: Xiao R]]
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[[Category: Xiao, R.]]
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[[Category: Yang Y]]
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[[Category: Yang, Y.]]
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[[Category: Hydrolase]]
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[[Category: Mpp]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Solution NMR Structure of the mitochondrial inner membrane domain (residues 164-251), FtsH_ext, from the paraplegin-like protein AFG3L2 from Homo sapiens, Northeast Structural Genomics Consortium Target HR6741A

PDB ID 2lna

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