4mdx

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{{STRUCTURE_4mdx| PDB=4mdx | SCENE= }}
 
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===Crystal structure of Bacillus subtilis MazF in complex with RNA===
 
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{{ABSTRACT_PUBMED_24120662}}
 
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==Function==
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==Crystal structure of Bacillus subtilis MazF in complex with RNA==
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[[http://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU]] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref>
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<StructureSection load='4mdx' size='340' side='right'caption='[[4mdx]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4mdx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MDX FirstGlance]. <br>
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[[4mdx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDX OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mdx OCA], [https://pdbe.org/4mdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mdx RCSB], [https://www.ebi.ac.uk/pdbsum/4mdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mdx ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024120662</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Patel, D J.]]
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[[Category: Large Structures]]
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[[Category: Simanshu, D K.]]
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[[Category: Patel DJ]]
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[[Category: Antitoxin]]
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[[Category: Simanshu DK]]
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[[Category: Endoa]]
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[[Category: Hydrolase-rna complex]]
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[[Category: Maze]]
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[[Category: Mazf]]
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[[Category: Mrna interferase]]
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[[Category: Toxin]]
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[[Category: Toxin-antitoxin complex]]
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[[Category: Toxin-mrna complex]]
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[[Category: Ydce]]
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Current revision

Crystal structure of Bacillus subtilis MazF in complex with RNA

PDB ID 4mdx

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