3acf

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{{STRUCTURE_3acf| PDB=3acf | SCENE= }}
 
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===Crystal Structure of Carbohydrate-Binding Module Family 28 from Clostridium josui Cel5A in a ligand-free form===
 
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{{ABSTRACT_PUBMED_20159017}}
 
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==About this Structure==
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==Crystal Structure of Carbohydrate-Binding Module Family 28 from Clostridium josui Cel5A in a ligand-free form==
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[[3acf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_josui Clostridium josui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ACF OCA].
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<StructureSection load='3acf' size='340' side='right'caption='[[3acf]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3acf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ruminiclostridium_josui Ruminiclostridium josui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ACF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ACF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3acf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3acf OCA], [https://pdbe.org/3acf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3acf RCSB], [https://www.ebi.ac.uk/pdbsum/3acf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3acf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q59290_RUMJO Q59290_RUMJO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/3acf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3acf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of a carbohydrate-binding module (CBM) family 28 domain of endoglucanase Cel5A from Clostridium josui have been determined in ligand-free and complex forms with cellobiose, cellotetraose, and cellopentaose as the first complex structures of this family. In the cleft of a beta-sandwich fold, the ligands are recognized by stacking interactions and hydrogen bonds. Conformations of the bound cellooligosaccharides are similar to those in crystals and solution but clearly different from the cellulose structure. Interestingly, the glucan chain bound on CBM28 is in the opposite direction of that bound to CBM17, although these families share significant structural similarity.
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==See Also==
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Recognition of cellooligosaccharides by a family 28 carbohydrate-binding module.,Tsukimoto K, Takada R, Araki Y, Suzuki K, Karita S, Wakagi T, Shoun H, Watanabe T, Fushinobu S FEBS Lett. 2010 Mar 19;584(6):1205-11. Epub 2010 Feb 14. PMID:20159017<ref>PMID:20159017</ref>
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*[[Glucanase|Glucanase]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020159017</ref><references group="xtra"/><references/>
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</div>
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[[Category: Cellulase]]
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<div class="pdbe-citations 3acf" style="background-color:#fffaf0;"></div>
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[[Category: Clostridium josui]]
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[[Category: Araki, Y.]]
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==See Also==
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[[Category: Fushinobu, S.]]
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*[[Glucanase 3D structures|Glucanase 3D structures]]
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[[Category: Karita, S.]]
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== References ==
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[[Category: Shoun, H.]]
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<references/>
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[[Category: Suzuki, K.]]
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__TOC__
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[[Category: Takada, R.]]
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</StructureSection>
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[[Category: Tsukimoto, K.]]
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[[Category: Large Structures]]
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[[Category: Wakagi, T.]]
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[[Category: Ruminiclostridium josui]]
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[[Category: Watanabe, T.]]
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[[Category: Araki Y]]
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[[Category: Beta-jellyroll]]
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[[Category: Fushinobu S]]
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[[Category: Cellulose-binding domain]]
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[[Category: Karita S]]
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[[Category: Glycosidase]]
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[[Category: Shoun H]]
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[[Category: Hydrolase]]
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[[Category: Suzuki K]]
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[[Category: Takada R]]
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[[Category: Tsukimoto K]]
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[[Category: Wakagi T]]
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[[Category: Watanabe T]]

Current revision

Crystal Structure of Carbohydrate-Binding Module Family 28 from Clostridium josui Cel5A in a ligand-free form

PDB ID 3acf

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