4jlw

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{{STRUCTURE_4jlw| PDB=4jlw | SCENE= }}
 
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===Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa===
 
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{{ABSTRACT_PUBMED_23989142}}
 
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==About this Structure==
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==Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa==
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[[4jlw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_lesb58 Pseudomonas aeruginosa lesb58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLW OCA].
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<StructureSection load='4jlw' size='340' side='right'caption='[[4jlw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jlw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_LESB58 Pseudomonas aeruginosa LESB58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JLW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlw OCA], [https://pdbe.org/4jlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jlw RCSB], [https://www.ebi.ac.uk/pdbsum/4jlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jlw ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Formaldehyde dehydrogenase (FDH) is a member of the zinc-containing medium-chain alcohol dehydrogenase family which oxidizes toxic formaldehyde to formate using NAD(+) as an electron carrier. Three-dimensional structures have been reported for FDHs from several different species. Most FDHs are dependent on glutathione for catalysis, but the enzyme from Pseudomonas putida is an exception. In this structural communication, the recombinant production, crystallization and X-ray structure determination at 2.7 A resolution of FDH from P. aeruginosa are described. Both the tetrameric assembly and the NAD(+)-binding mode of P. aeruginosa FDH are similar to those of P. putida FDH, which is in good agreement with the high sequence identity (87.97%) between these two proteins. Preliminary enzymatic kinetics studies of P. aeruginosa FDH also revealed a conserved glutathione-independent `ping-pong' mechanism of formaldehyde oxidization.
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==Reference==
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Structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa: the binary complex with the cofactor NAD+.,Liao Y, Chen S, Wang D, Zhang W, Wang S, Ding J, Wang Y, Cai L, Ran X, Wang X, Zhu H Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):967-72. doi: , 10.1107/S174430911302160X. Epub 2013 Aug 19. PMID:23989142<ref>PMID:23989142</ref>
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<ref group="xtra">PMID:023989142</ref><references group="xtra"/><references/>
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[[Category: Pseudomonas aeruginosa lesb58]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Cai, L J.]]
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</div>
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[[Category: Chen, S.]]
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<div class="pdbe-citations 4jlw" style="background-color:#fffaf0;"></div>
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[[Category: Ding, J F.]]
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== References ==
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[[Category: Liao, Y P.]]
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<references/>
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[[Category: Ran, X Y.]]
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__TOC__
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[[Category: Wang, D L.]]
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</StructureSection>
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[[Category: Wang, S.]]
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[[Category: Large Structures]]
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[[Category: Wang, Y M.]]
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[[Category: Pseudomonas aeruginosa LESB58]]
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[[Category: Zhu, H X.]]
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[[Category: Cai LJ]]
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[[Category: Dehydrogenase]]
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[[Category: Chen S]]
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[[Category: Nad+ binding]]
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[[Category: Ding JF]]
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[[Category: Oxidoreductase]]
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[[Category: Liao YP]]
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[[Category: Rossmann fold]]
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[[Category: Ran XY]]
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[[Category: Zinc binding]]
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[[Category: Wang DL]]
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[[Category: Zinc finger]]
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[[Category: Wang S]]
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[[Category: Wang YM]]
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[[Category: Zhu HX]]

Current revision

Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa

PDB ID 4jlw

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