4ks5

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{{STRUCTURE_4ks5| PDB=4ks5 | SCENE= }}
 
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===Influenza neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid===
 
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{{ABSTRACT_PUBMED_24129600}}
 
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==About this Structure==
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==Influenza neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid==
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[[4ks5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/duck/ukraine/1/1963(h3n8)) Influenza a virus (a/duck/ukraine/1/1963(h3n8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KS5 OCA].
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<StructureSection load='4ks5' size='340' side='right'caption='[[4ks5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ks5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Ukraine/1/1963(H3N8)) Influenza A virus (A/duck/Ukraine/1/1963(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KS5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.699&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SO:(3S,4R,5R)-4-(ACETYLAMINO)-3-[4-(2-HYDROXYPROPAN-2-YL)-1H-1,2,3-TRIAZOL-1-YL]-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>1SO</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ks5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ks5 OCA], [https://pdbe.org/4ks5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ks5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ks5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ks5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0A480_I63A3 Q0A480_I63A3]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The influenza virus neuraminidase (NA) is essential for the virus life cycle. The rise of resistance mutations against current antiviral therapies has increased the need for the development of novel inhibitors. Recent efforts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in addition to the primary catalytic subsite in order to increase specificity and reduce the likelihood of resistance. This study details structural and in vitro analyses of a class of inhibitors that bind uniquely in both subsites. Crystal structures of three inhibitors show occupation of the 150-cavity in two distinct and novel binding modes. We believe these are the first nanomolar inhibitors of NA to be characterized in this way. Furthermore, we show that one inhibitor, binding within the catalytic site, offers reduced susceptibility to known resistance mutations via increased flexibility of a pendant pentyloxy group and the ability to pivot about a strong hydrogen-bonding network.
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==Reference==
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Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.,Kerry PS, Mohan S, Russell RJ, Bance N, Niikura M, Pinto BM Sci Rep. 2013 Oct 16;3:2871. doi: 10.1038/srep02871. PMID:24129600<ref>PMID:24129600</ref>
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<ref group="xtra">PMID:024129600</ref><references group="xtra"/><references/>
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[[Category: Kerry, P S.]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Russell, R J.M.]]
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</div>
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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<div class="pdbe-citations 4ks5" style="background-color:#fffaf0;"></div>
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[[Category: Sialidase]]
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==See Also==
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Kerry PS]]
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[[Category: Russell RJM]]

Current revision

Influenza neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid

PDB ID 4ks5

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