4hpw

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{{STRUCTURE_4hpw| PDB=4hpw | SCENE= }}
 
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===Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine===
 
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==Function==
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==Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine==
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[[http://www.uniprot.org/uniprot/SYY_METJA SYY_METJA]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
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<StructureSection load='4hpw' size='340' side='right'caption='[[4hpw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HPW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3YM:3-METHOXY-L-TYROSINE'>3YM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hpw OCA], [https://pdbe.org/4hpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hpw RCSB], [https://www.ebi.ac.uk/pdbsum/4hpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hpw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
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==About this Structure==
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==See Also==
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[[4hpw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_dsm_2661 Methanocaldococcus jannaschii dsm 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPW OCA].
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Methanocaldococcus jannaschii dsm 2661]]
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</StructureSection>
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Dong, J.]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Gao, F.]]
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[[Category: Dong J]]
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[[Category: Gong, W.]]
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[[Category: Gao F]]
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[[Category: Li, H.]]
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[[Category: Gong W]]
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[[Category: Li, J.]]
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[[Category: Li H]]
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[[Category: Lu, Y.]]
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[[Category: Li J]]
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[[Category: Mukherjee, A.]]
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[[Category: Lu Y]]
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[[Category: Nilges, M.]]
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[[Category: Mukherjee A]]
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[[Category: Ouyang, H.]]
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[[Category: Nilges M]]
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[[Category: Wang, J.]]
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[[Category: Ouyang H]]
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[[Category: Xiaoxuan, L.]]
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[[Category: Wang J]]
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[[Category: Yang, Y.]]
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[[Category: Xiaoxuan L]]
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[[Category: Zhou, Q.]]
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[[Category: Yu Y]]
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[[Category: 3-o-methyl tyrosine incorporation]]
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[[Category: Zhou Q]]
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[[Category: Ligase]]
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[[Category: Trna]]
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Current revision

Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine

PDB ID 4hpw

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